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Updates every hour. Last Updated: 3-Nov-2025 03:11 ET (3-Nov-2025 08:11 GMT/UTC)
How a prehistoric genetic split helped plants conquer polluted soils
Nanjing Agricultural University The Academy of ScienceAn ancient genetic event may hold the key to how plants survive in metal-contaminated environments. Scientists have discovered that a duplication of phytochelatin synthase (PCS) genes—crucial enzymes for detoxifying toxic metals—occurred millions of years ago and remains conserved in flowering plants today. These twin gene copies, known as D1 and D2, evolved distinct but complementary functions: while D1 plays a general role in detoxification, D2 exhibits exceptional catalytic activity against cadmium and arsenic. Functional tests in Malus domestica (MdPCS1, MdPCS2) and Medicago truncatula (MtPCS1, MtPCS2) revealed that both copies are indispensable for maintaining metal balance, unveiling a deep evolutionary strategy for resilience.
- Journal
- Horticulture Research
Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors
Chinese Medical Journals Publishing House Co., Ltd.This review focuses on how immunosenescence and inflammaging impact immune checkpoint inhibitor (ICI) efficacy and safety in older cancer patients.
Immunosenescence impairs T/NK cell function (e.g., reduced TCR diversity, CD28⁻CD57⁺ senescent T cells) and expands immunosuppressive cells (Tregs, MDSCs). Inflammaging causes inflammatory imbalance via SASP and DAMPs. Both reduce ICI efficacy and increase immune-related adverse events (irAEs).
Its innovation lies in systematically linking these age-related factors to ICI outcomes. Clinically, it suggests using SIP⁺ T cell ratio/cytokine levels to predict efficacy, and proposes a scoring system to optimize elderly patients' ICI therapy.
- Journal
- Cancer Pathogenesis and Therapy
Co-culture models for investigating cellular crosstalk in the glioma microenvironment
Chinese Medical Journals Publishing House Co., Ltd.This review summarizes 2D (direct/indirect contact, e.g., Transwell) and 3D (cell/tissue/organoid-based, microfluidic, 3D-bioprinted) co-culture models for studying glioma-tumor microenvironment (TME) cell crosstalk (glioma with endothelial cells, neurons, immune cells, etc.).
Its innovation lies in systematically integrating diverse models and emphasizing understudied multi-cell interactions. Clinically, these models enable mechanistic research and drug screening, providing insights for developing TME-targeted therapies to improve glioma treatment efficacy.
- Journal
- Cancer Pathogenesis and Therapy
Charting the future of carbon fiber composite recycling
Biochar Editorial Office, Shenyang Agricultural University- Journal
- Carbon Research
The brain may not be a muscle, but it still needs exercise
George Mason University- Journal
- Educational Gerontology
New study reveals corporate directors on charity boards drive pro-corporate lobbying
Institute for Operations Research and the Management Sciences- Journal
- Management Science
Crucial protein enables immune system memory
University of Missouri-ColumbiaResearchers at the University of Missouri School of Medicine have recently found that a certain protein may have a large influence on how the immune system functions and 'remembers' past infections.
- Journal
- Frontiers
How a tiny zinc finger protein determines tomato fruit size
Nanjing Agricultural University The Academy of ScienceThe secret to tomato size lies within the flower's core. Scientists have discovered that the gene SlKNUCKLES (SlKNU), which encodes a zinc finger protein, serves as a key switch that determines fruit size by regulating floral meristem activity—the tissue responsible for forming reproductive organs.
- Journal
- Horticulture Research
Tomato gene SlKNU unlocks bigger fruits by taming floral stem cells
Nanjing Agricultural University The Academy of ScienceThe size of a tomato fruit begins with its flower. Scientists have revealed that the gene SlKNUCKLES (SlKNU), which encodes a zinc finger protein, plays a decisive role in determining tomato fruit size by regulating the activity of floral meristems—the tissue that gives rise to reproductive organs.
- Journal
- Horticulture Research