Researchers at the University of Pennsylvania have uncovered the first natural example of granular jamming, a process where loose particles lock into place under pressure, in the skeleton of a soft coral. The discovery explains a long-observed mystery in biology and could inspire new designs for medical devices, robotics and protective gear.

Drugs to treat inflammatory and autoimmune diseases — such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome — act mainly through the glucocorticoid receptor (GR). This essential protein regulates vital processes in various tissues, so understanding its structure and function at the molecular level is essential for designing more effective and safer drugs. Now, a study published in the journal Nucleic Acids Research (NAR) has revealed the mechanism of multimerization — the association of different molecules to form complex structures — of the glucocorticoid receptor, a process critical to its physiological function.

This study obtained historical genomes (~1900) of 46 Eastern honeybees. A comparison between historical and contemporary genomes revealed a decline in genetic diversity. Genes related to the nervous system have undergone rapid evolution over the past century, including key insecticide targets nAchRs. Insecticide exposure experiments confirmed genomic divergence among populations: those from central China exhibited stronger pesticide tolerance compared to populations from Malaysia.

For decades, scientists have known that bacteria can exchange genetic material in a process called horizontal gene transfer. Research by Professor Mittra’s group suggests that horizontal transfer also happens in mammals via fragments of DNA known as cell-free chromatin particles that are released from dying cells. Once inside new host cells, the chromatin particles acquire novel functions and act as autonomous “satellite” genomes. This discovery may redefine mammalian genomics and evolution.