Interactions between diet and the gut microbiome have been shown to have broad roles in shaping host metabolism and health. Now, researchers at the Human Biology Microbiome Quantum Research Center (WPI-Bio2Q, directed by Kenya Honda, M.D., Ph.D., co-senior author of the study) and Keio University, together with researchers from City of Hope and the Broad Institute, show how specific gut microbes are able to interpret diet and subsequently drive the conversion of white adipose tissue into beige fat, a metabolically active form of fat that burns energy instead of storing it.

The study, which has been published in Nature, also identified the molecular pathways that connect these aspects of dietary protein intake, microbial metabolism, and the host’s fat-burning response.

“These findings show, in a mechanistic way, how gut microbes are able to act as an important mediator of dietary cues, and how these bacteria are able to produce signals that shape host metabolism” said Scott Behie, member of WPI-Bio2Q and co-author of the study.

The honey bee “waggle dance” is an advanced form of animal communication that conveys critical information about food sources. A new study finds that the performing bee is not simply broadcasting a predetermined message. Rather, the precision of the performer’s directions depends on the audience.

The honey bee “waggle dance” is an advanced form of animal communication that conveys critical information about food sources. A new study finds that the performing bee is not simply broadcasting a predetermined message. Rather, the precision of the performer’s directions depends on the audience.

In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first steps towards folding proteins into their correct three-dimensional structures. This discovery was made by an international research team led by scientists from the Center for Molecular Biology of Heidelberg University. They found that the NAC complex binds to the nascent protein building-blocks formed by the ribosome, i.e., the amino acid chains, and initiates the folding that is essential for functional proteins. According to the scientists, the research results provide not only new findings on protein synthesis but also insights into cellular strategies to avoid incorrect folding, which can lead to serious illnesses.