Researchers at The University of Texas MD Anderson Cancer Center have identified a key enzyme – RNase H2 – that helps triple-negative breast cancer (TNBC) cells survive high levels of DNA replication stress. Because many breast cancer therapies work by causing replication stress, these results suggest RNase H2 is a promising treatment target.

People with obesity face a significantly increased risk of atherosclerosis, and consequently heart attack and stroke. This elevated risk is largely driven by chronic inflammation in the blood vessels, which is more common in severe obesity. A new study led by Florian Kiefer at the Division of Endocrinology and Metabolism, MedUni Vienna, has now identified brown adipose tissue (brown fat) as a potential protective factor for vascular health. The findings, published in Atherosclerosis, Thrombosis and Vascular Biology, show for the first time in humans that individuals with obesity and active brown fat exhibit significantly lower arterial inflammation.

Blood tests measuring the aging of certain white blood cells can predict cognitive and mood-related symptoms of depression, rather than physical symptoms. 

The findings, published in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, bring researchers closer to identifying a biomarker for detecting the mood disorder, which affects nearly one in five US adults.