Tiny cell messengers in obese individuals accelerate Alzheimer’s-linked plaque buildup in the brain
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Updates every hour. Last Updated: 6-Oct-2025 21:11 ET (7-Oct-2025 01:11 GMT/UTC)
In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and neurodegenerative diseases / publication in ‘Molecular Cell’
Researchers at Integra Therapeutics, in collaboration with the Pompeu Fabra University (UPF) Department of Medicine and Life Sciences (MELIS) and the Center for Genomic Regulation (CRG), have designed and experimentally validated new synthetic proteins that can edit the human genome more efficiently than proteins provided by nature. This work, a global pioneer published today in the journal Nature Biotechnology, will be of great use in improving the current gene editing tools used in biotechnology research and personalized medicine by developing cellular (CAR-T) and gene therapies, especially to treat cancer and rare diseases.
Kyoto, Japan -- With their massive flapping ears and long trunks, it isn't hard to believe that elephants tend to rely on acoustic and olfactory cues for communication. They use gestures and visual displays to communicate as well, but we don't really know how much. Visual communication research has mainly focused on species that are primarily visual, like nonhuman primates.
A previous study demonstrated that African savanna elephants can recognize human visual attention based on a person's face and body orientation, but this had yet to be investigated in their Asian cousins. Asian elephants split from African elephants millions of years ago, so their behavior and cognition differ in some aspects.
Motivated to find out whether Asian elephants share this ability with African elephants, a team of researchers at Kyoto University turned their attention to elephants in Thailand.
A new analytical method is revealing how conservationists can further boost breeding programmes dedicated to saving some of the world’s most threatened species, according to new research led by the University of Sheffield and ZSL.
Conservation zoos, and the global breeding programmes they facilitate, are vital to maintaining or restoring populations and boosting genetic diversity of threatened birds. But not every egg produced in a breeding programe hatches into a chick.
New research by an international team of scientists - from ZSL’s Institute of Zoology, the University of Sheffield, University College London, University of Canterbury and the Department of Conservation in Aotearoa New Zealand - has shown that new diagnostic methods could help amplify the success of conservation breeding programmes, by offering a better understanding of why eggs don’t hatch.