Exploring REM sleep's role in PTSD: New insights from the University of Texas at San Antonio research
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Updates every hour. Last Updated: 6-May-2025 16:09 ET (6-May-2025 20:09 GMT/UTC)
Researchers at the UTSA Sleep and Memory Computational Lab are studying how Rapid Eye Movement (REM) sleep could influence individuals who are regularly exposed to stressful experiences and are at higher risk of developing Post Traumatic Stress Disorder (PTSD).
The study, led by UTSA psychology professor Itamar Lerner, involves collaboration with first responders, such as firefighters and law enforcement personnel. The researchers examined their baseline levels of REM sleep, also known as “dream sleep,” and how that could have lasting effects on them over time.
“Our ongoing hypothesis is that REM sleep affects your ability to process threatening situations in two different ways, based on the predictiveness of the cues associated to the threat,” Lerner said. “Proving that would not only have clinical implications but also tell us something fundamental about the memory processes that occur in the brain and how sleep affects them.”
This research began as a pilot study two years ago. Since then, Lerner has secured a five-year, $725,000 CAREER award from the National Science Foundation for his research. This funding will allow his team to recruit more than 100 participants overall, with nearly 70 participants already enrolled.
Researchers at Pennington Biomedical Research Center have revealed critical insights into how impaired mitochondrial dynamics and quality control mechanisms in skeletal muscle influence insulin sensitivity in patients with Type 2 Diabetes, or T2D. The study, titled "Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients with Type 2 Diabetes," was recently published in the Journal of Cachexia, Sarcopenia and Muscle.
The research team, led by Pennington Biomedical Executive Director Dr. John Kirwan, focused on the significance of deubiquitinating enzymes, or DUBs, in regulating mitochondrial dynamics within skeletal muscle. Findings suggest that mitochondrial fragmentation can bypass defects in mitophagy, the process by which cells remove damaged mitochondria, to sustain skeletal muscle quality control in patients with T2D. This adaptation may help maintain mitochondrial function despite impaired mitophagy.
Ignacio J. Melero-Jiménez, a researcher at the Department of Botany and Plant Physiology of the University of Malaga, has collaborated with an international scientific team that has shown, based on an experimental system that reproduces a mutualistic microbial community, that the most common evolutionary solution for two co-dependent organisms to survive extreme environmental change could be to become self-sufficient.