Artificial intelligence models that automatically label organs and anatomical structures in medical images are increasingly used to study large public imaging datasets, but comparing these tools is difficult when no expert reference annotations exist. A recent study developed an open-source framework for evaluating and comparing AI-based anatomy segmentation models using inter-model agreement rather than ground truth. Applying the approach to six widely used segmentation models and chest CT scans from the National Lung Screening Trial, the researchers normalized all model outputs to follow standard lexicon, and stored the result in a common medical imaging format. Normalized representation made it possible to visualize and compare model outputs, and analyze how consistently each model segmented key structures such as the lungs, heart, ribs, vertebrae, and sternum. The results show strong agreement across models for lung segmentation, but substantial inconsistencies and systematic errors for bones and some cardiac structures, particularly among models trained on similar data. By combining quantitative agreement metrics with interactive visualization tools, the framework helps identify reliable models and flag problem cases, offering a practical way to guide model selection and large-scale reuse of AI-generated annotations.

Researchers at UMass Chan Medical School have developed a gene editing technology that allows for the precise and efficient insertion of very large DNA segments into the human genome.

When water fleas grow up in the vicinity of predators, they change their body shape. Crowns of thorns or large heads make them more difficult to eat. Researchers in Bochum provide insight into the underlying mechanisms.

In a new study, University of Washington scientists eavesdropped on Cook Inlet belugas to better understand the context of their calls and how human noise is impacting their ability to communicate with each other.

Research has found that children with higher genetic susceptibility to schizophrenia show decreases in frontal cortical surface area during early adolescence, in contrast to the regional expansion observed in children with low genetic susceptibility. This suggests that individuals with high genetic liability for schizophrenia may already show deviations in their neurodevelopmental trajectories before symptoms typically appear in young adulthood. The findings from the new study in Biological Psychiatry, published by Elsevier, provide critical insights for refining developmental models of schizophrenia and for informing the timing of preventive interventions.

A research team has pinpointed PTCHD1-AS, a long non-coding RNA gene on the X chromosome, as a contributor to increased likelihood of ASD in males. Notably, deletions within PTCHD1-AS influence social interaction and repetitive behaviours, while leaving cognition unaffected.   

Scientists from EMBL and the University of Virginia discovered a new protein while investigating what happens to yeast cells when stressed. When yeast is deprived of glucose, a newly identified protein named SNOR attaches to its ribosomes, resulting in a dormant state that preserves resources and energy. SNOR’s more vital role comes in restarting protein synthesis once nutrients become available again. This study is an example of how new technologies, such as cellular cryo-electron tomography (cryo-ET) and visual proteomics, offer a ‘higher-definition’ approach to conducting structural biology, enabling scientists to discover the role of previously uncharacterised proteins.

BUFFALO, NY – May 13, 2026 – A new case report was published in Volume 17 of Oncotarget on May 4, 2026, titled “Laryngeal leiomyosarcoma: A rare case report and literature review.”

Woods Hole, Mass. (May 13, 2026) – Storm petrels are among the smallest and most mysterious seabirds. Until recently, the use of biologgers to track their movements was impossible. A new study published in the Proceedings of the Royal Society: Biology Letters reveals that they routinely travel hundreds of kilometers while deliberately seeking crosswinds, an unexpected strategy that slows their flight but may help them survive above the open ocean.