An international team of scientists, co-led by researchers at Trinity College Dublin and the University of Florida, has cracked a decades-old mystery in human biology: how our bodies absorb a micronutrient that we rely on for everything from healthy brain function to guarding against cancer. Queuosine, a microscopic molecule first discovered in the 1970s, is a vitamin-like micronutrient that we can't make ourselves but can only get from food and our gut bacteria. It’s vital to our health, yet its importance went unnoticed for decades. Now, in a study published this week in leading international journal Proceedings of the National Academy of Sciences (PNAS), researchers have discovered the gene that allows queuosine to enter the cells, a discovery that opens the door for potential therapies to be created to leverage the micronutrient’s role in cancer suppression, memory and how the brain learns new information. 

A research team led by the Institute of Evolutionary Biology (IBE), a mixed research centre belonging to the Spanish National Research Council (CSIC) and Pompeu Fabra University (UPF), points for the first time to a mechanism of rapid, massive genomic reorganisation which could have played a part in the transition of marine to land animals 200 million years ago. The team has shown that marine annelids (worms) reorganised their genome from top to bottom, leaving it unrecognisable, when they left the oceans.  Their observations are consistent with a punctuated equilibrium model, and could indicate that not only gradual but sudden changes in the genome could have occurred as these animals adapted to terrestrial settings. The genetic mechanism identified could transform our concept of animal evolution and revolutionise the established laws of genome evolution.