The multidrug-resistant pathogen Acinetobacter baumannii (A. baumannii) is a global health concern. Its surface capsular polysaccharides and lipopolysaccharides, which are structurally diverse and often contain rare, non-classical sugars, are major virulence factors. These glycans represent promising targets for novel therapeutics. Notably, glycoconjugate vaccines based on these structures elicit protective antibodies and confer effective immunity in animal models, highlighting their potential for combating infections.

Tigers don’t roam across Asia as they used to, but on one island in Indonesia a population of critically endangered Sumatran tigers may have found a habitat that supplies them with enough space, intact forests, and prey to thrive and raise their young. To examine tiger population densities, researchers working alongside local rangers installed infrared cameras in forests outside the national park system. Their work, in collaboration with the government of Aceh province, resulted in almost three times more images being taken and individual tigers being identified than during previous surveys. Dedicated protection efforts are the main reason for tigers’ persistence in this ecosystem, which highlights the necessity of such measures, the team said.

Functionalized single-walled carbon nanotubes (SWCNTs) effectively delivered the amh/amhy plasmid into all-female mandarin fish via immersion. At 40 mg/L, plasmid DNA and transcripts were detected in gonads within 7-14 days. By 60-120 days, some fish developed masculinized gonads with downregulated foxl2/cyp19a1a and upregulated amh/dmrt1. The study demonstrates SWCNTs as a viable gene delivery tool in fish and confirms the crucial role of amh/amhy in sex determination via the amhrII/smads pathway activating dmrt1.

A machine learning-based resource developed at St. Jude Children’s Research Hospital predicts which intrinsically disordered regions can drive the formation of biomolecular condensates and links those proteins to RNA biology.