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Medicine & Health

Updates every hour. Last Updated: 30-Oct-2026 07:15 ET (30-Oct-2026 11:15 GMT/UTC)

First use of precision editing to study human embryo development reveals role of master gene

University of Cambridge
Peer-Reviewed Publication

- Scientists have, for the first time, used an extremely precise genome editing technique called base editing to study gene function in human embryos.

- Using the technique, they found that a gene called NANOG is essential for forming the future body from an embryo. Without it, the embryo loses its ability to differentiate into different body tissues.

- This reveals fundamental differences between early development in human and mouse embryos, underscoring the importance of directly investigating human embryonic development.

Journal: Nature
Funder: Wellcome Trust, Medical Research Council, Cancer Research UK

Study: leveraging AI to enhance how physicians approach sepsis care

University of California - San Diego
Peer-Reviewed Publication

Researchers find by utilizing artificial intelligence (AI), physicians can reduce the time and resources needed to develop accurate assessments for sepsis care

Journal: JAMA Network Open

Smell and taste disturbances among GLP-1 RA users

JAMA Network
Peer-Reviewed Publication

About The Study: The findings of this study suggest that glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy is associated with a higher risk of smell and taste disturbance, highlighting the need for closer monitoring and greater public health awareness. Future research is required to validate these findings and to further explore the mechanisms underlying this association.

Journal: JAMA Otolaryngology–Head & Neck Surgery

AI framework aids target discovery for CAR T cell therapy

University of Pennsylvania School of Medicine
Peer-Reviewed Publication

Leading CAR T cell therapy researchers from Penn Medicine have developed a human-in-the-loop artificial intelligence (AI) framework that firmly centers scientists’ expertise to find viable target antigens for CAR T cell therapy.

Journal: Cell

Integrative transcriptomic and metabolomic analyses of puerarin against cholestatic liver fibrosis

FAR Publishing Limited
Peer-Reviewed Publication

A new study published in Current Molecular Pharmacology reveals that puerarin, a bioactive isoflavone from traditional Chinese medicine, alleviates cholestatic liver fibrosis in a rat model by modulating extracellular matrix deposition, regulating the PI3K-Akt signaling pathway, and promoting the conjugation of toxic bile acids, offering a potential new therapeutic strategy for this challenging condition.

Journal: Current Molecular Pharmacology

UCLA researchers awarded $1.7 million Department of Defense grant to advance next-generation CAR T-cell therapies for prostate cancer

University of California - Los Angeles Health Sciences
Grant and Award Announcement

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center have received a $1.7 million grant from the U.S. Department of Defense’s Congressionally Directed Medical Research Programs (CDMRP) to develop new strategies to improve CAR T-cell therapies for metastatic castration-resistant prostate cancer, an advanced form of the disease with limited treatment options.

Microscale hydrogel fibers could enable imaging inside tiny tissue structures

Optica
Peer-Reviewed Publication

Researchers combined adaptive optics and parallel optical coherence tomography to capture high-speed, 3D views of individual cells in the living retina. This non-invasive advance could drastically improve the early detection and monitoring of chorioretinal diseases.

Lifestyle intervention linked to slower biological aging markers in older men

Impact Journals LLC
Peer-Reviewed Publication

BUFFALO, NY — June 25, 2026 — A new research paper was published in Volume 18 of Aging on May 29, 2026, titled “Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled trial.”

Journal: Aging-US

Targeting fPRDM16 to restore collagen phagocytosis: A mechanism to counteract the persistent fibrosis in aging lungs

FAR Publishing Limited
Peer-Reviewed Publication

A recent study in Current Molecular Pharmacology reveals that age-related decline of fPRDM16 in lung fibroblasts impairs collagen I phagocytosis via a mitochondria-lysosome dysfunction loop, driving persistent pulmonary fibrosis. Overexpressing fPRDM16 restored phagocytosis, improved lysosomal acidification, and reduced mitochondrial oxidative stress, presenting a novel therapeutic target for promoting fibrosis resolution in aging.

Journal: Current Molecular Pharmacology