The FXYD proteins (FXYD domain-containing ion transport regulators) are a family of seven distinct proteins that play crucial roles in regulating Na+/K+-ATPase (NKA) activity. Each of these proteins is characterized by a conserved 35-amino-acid FXYD domain, essential for their functions, and exhibits tissue-specific expression, contributing to diverse roles in various tissues.

Research over the years has highlighted the role of the FXYD proteins in regulating numerous physiological processes, including ion transport, neuronal activity, cell adhesion, and migration; conversely, their altered expression has been implicated in the progression of various diseases, such as cancer, neurological, cardiovascular, and renal diseases, and others. Understanding the FXYD proteins and their underlying regulatory mechanisms may therefore aid in identifying novel therapeutic targets.

Widely used eye ointments can cause glaucoma implants to swell and potentially rupture, according to new research from Nagoya University in Japan. This study is the first to show, using clinical and experimental evidence, that petrolatum-based eye ointments can compromise the PRESERFLO® MicroShunt, an implant used in over 60 countries to treat glaucoma.

Developed by a consortium of 30 public and private partners, ACCESS-AD (“Advancing Clinical Care and Equity through Scalable Solutions in Alzheimer’s Disease diagnosis and treatment”) is focused on bringing innovations to routine clinical practice for Alzheimer’s disease, supporting timely diagnosis, treatment and monitoring across diverse healthcare settings. Launching on 13 January 2026, ACCESS-AD is funded for a period of 5 years by the Innovative Health Initiative (IHI), an EU Public-Private Partnership supporting health research and innovation. 

A new study led by researchers at the University of Waterloo found that members of many Indigenous communities who eat certain types of locally harvested waterfowl, especially ducks with mixed or fish-based diets, may have higher levels of both mercury and healthy omega-3 fatty acids in their blood.

University of Auckland researchers have discovered that a part of the brain may be behind high blood pressure

As Australians return to work after the holidays, many will be reflecting on their health and wellbeing goals for the year ahead. New research reveals that while workplace factors like long hours, work-related stress and shift work do influence high-risk drinking, personal and social factors play an even bigger role.

A research team at The University of Osaka revealed that the loss of heterochromatin can cause a chain reaction leading to genetic changes and the subsequent development of diseases including cancer. Using fission yeast, the study specifically found that loss of Clr4, which encodes a methyltransferase, can induce an increase in R-loop levels at pericentromeric repeats, and the later conversion of R-loops into ADR-loops can prompt gross chromosomal rearrangements.