For centuries, the process by which the cinchona tree produces its valuable alkaloids, including the life-saving quinine used to treat malaria, was shrouded in mystery. Now, a research team from the Max Planck Institute for Chemical Ecology in Jena, together with colleagues from the University of Georgia, has uncovered the secret. In a new study, the scientists demonstrate how the plant sequentially builds up the complex molecular framework characteristic of quinine. The researchers identified the enzymes responsible for catalyzing the chemical reactions that take place inside the plant. The study opens up new avenues for the sustainable and efficient laboratory production of natural substances such as quinine and related active ingredients.

WashU Medicine researchers found that stopping GLP-1 drugs such as semaglutide and tirzepatide — even temporarily — elevates the risk of heart attack, stroke and death compared to staying on the medication continuously.

AI researchers at Mass General Brigham have two new papers showing that the thymus, an immune system organ long assumed irrelevant after puberty, may actually be a key driver of longevity, disease risk, and response to cancer treatment. In their first study, they used AI to analyze CT scans from more than 27,000 adults, and found inviiduals with high "thymic health" scores had a ~50% lower risk of death, 63% lower cardiovascular mortality, and 36% lower lung cancer risk compared to those with low scores. In a second study of 1,200 cancer patients treated with immunotherapy, the researchers found those with stronger thymic health had a 37% lower risk of cancer progression and a 44% lower risk of death. Together, the findings point to a major role of the thymus in adult health, and its potential as a target for screening and personalized medicine.

Women who enter natural menopause before age 40 face about a 40% higher lifetime risk of developing coronary heart disease than women who experience menopause later, according to a large Northwestern Medicine study that is the first to calculate lifetime heart risk associated with premature menopause. The findings suggest that doctors should routinely ask women about age at menopause, using the menopausal transition as an opportunity to identify higher-risk women and intervene earlier.