A randomized, controlled trial found that patients assigned to a comprehensive navigation service, which helps patients understand the complexities of the medical system, had a significantly higher rate of self-reported access to needed resources three months after enrollment compared with control involving traditional signposting (50.3% vs 35.8%). The study compared two levels of social prescribing among 326 randomized patients in Ontario, Canada, and their impact on access to needed health and social resources and equity for Ontario’s Francophone minority population.