Rotator cuff tears often heal with stiff, dysfunctional scar tissue, limiting recovery. A new study reveals why tendon regeneration fails after injury. Using single-cell profiling of tens of thousands of cells from patient tendon samples, the study maps the first atlas of human tendon scarring and identifies pro-fibrotic stem cells, senescent tendon cells, scar-forming macrophages, and transitioning endothelial cells. Targeting key fibrotic signals reduced scarring in animal models, suggesting new therapeutic strategies.

A research team led by Dr. Mi-Young Son at the National Agenda Research Institute of the Korea Research Institute of Bioscience and Biotechnology (KRIBB) has established a new evaluation platform that can more accurately assess gastrointestinal toxicity of drug candidates before they enter clinical trials.

This March, join the Alliance for Clinical Trials in Oncology (Alliance) and the Alliance Foundation Trials (AFT) in spotlighting colorectal cancer, the second leading cause of cancer-related death in the United States, behind only lung cancer, according to the National Cancer Institute. Last year, an estimated 155,000 Americans received a diagnosis of colon or rectal cancer, and about 53,000 died from the disease. Alliance has 10 active trials focused on improving treatments for colorectal cancers as well as others aimed at ways to prevent the disease or catch it very early when symptoms are most easily and effectively treated.

Birth order, a non-genetic factor, may influence early neurodevelopment. A nationwide Japanese birth cohort study based on sibling pairs suggests that differences in neurodevelopment emerge during the first year of life. Second-born infants scored slightly lower than firstborns across several domains and had lower levels of parental engagement. The study suggests that differences in caregiver-reported parental engagement may partly account for these small but consistent early developmental gaps, though their long-term clinical significance remains unclear.