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Medicine & Health

Updates every hour. Last Updated: 29-Oct-2026 01:16 ET (29-Oct-2026 05:16 GMT/UTC)

Novel AI model accurately detects key gene mutations and predicts biomarkers across 32 cancer types

Elsevier
Peer-Reviewed Publication

Researchers have developed a novel AI model that can analyze a routine whole histopathology image and simultaneously predict cancer subtype, specific genetic mutations, and survival outcomes across 32 different solid cancers rather than focusing on a single cancer type. The findings from the study in The American Journal of Pathology, published by Elsevier, highlight the potential of computational pathology to connect routine diagnostic imaging with molecular oncology.

Journal: American Journal Of Pathology
Funder: Australian National Health and Medical Research Council Leadership Award

Traumatic brain injury in Pakistan linked to poor long-term survival

Weill Cornell Medicine
Peer-Reviewed Publication

Traumatic brain injury (TBI) in Pakistan is associated with a high risk of death and disability long after the initial injury, even in mild to moderate cases, according to two new studies in JAMA Network Open led by Weill Cornell Medicine researchers.

Journal: JAMA Network Open

Half of prostate cancer focal therapy use falls outside current guideline-supported groups

University of Pittsburgh
Peer-Reviewed Publication

As focal therapy gains popularity as a less invasive treatment option for some men with prostate cancer, a national study led by researchers at the University of Pittsburgh found that some men may be receiving treatment that is either unnecessary or not aggressive enough for their cancer.

Journal: JAMA

Active surveillance use for favorable-risk prostate cancer in a Veterans Affairs population

JAMA Network
Peer-Reviewed Publication

About the Study: This Research Letter describes the incidence and quality of active surveillance use for prostate cancer in the national Veterans Affairs Healthcare System. In the VA health system, active surveillance or watchful waiting for favorable-risk prostate cancer increased from 27% to 93% for low-risk disease and from 14% to 61% for favorable intermediate-risk disease. Overall, the study suggests that many veterans with favorable-risk prostate cancer are avoiding unnecessary treatment, but some disparities in care still need attention.

Journal: JAMA

Focal therapy for prostate cancer

JAMA Network
Peer-Reviewed Publication

About the Study: This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers. In a cohort of about 1.18 million patients with nonmetastatic prostate cancer, about half of focal therapy procedures occurred in low-, high-, or very-high-risk disease, settings in which routine use is not supported by current guidelines. Overall use remained uncommon.

Journal: JAMA

Treatment selection for major depressive disorder in Veterans Health Administration outpatients

JAMA Network
Peer-Reviewed Publication

About the Study: In this cohort study of 1 582 834 veterans with MDD, most received recommended treatment, but there was an increasing trend in the proportion who did not (up to 10.2% in 2025). The findings require further investigation into potential undertreatment of VHA outpatients with MDD and underscore the need to examine mental health service availability and other factors that influence treatment selection decisions.

Journal: JAMA Network Open

Military-related toxic exposures and mental and physical health in US veterans

JAMA Network
Peer-Reviewed Publication

About the Study: This cross-sectional study examines the prevalence of exposures to Agent Orange and open-air burn pits and their independent associations with mental and physical health outcomes among US veterans.

Journal: JAMA Network Open

A few minutes of sprinting could make a bigger impact than 90 minutes of moderate running

Rockefeller University
Peer-Reviewed Publication

Brief bursts of intense exercise trigger a molecular response linked to a lower risk of cardiovascular and metabolic disease and associated with slower biological aging.

Journal: Cell Reports Medicine

Astrocytes directly regulate brain circuits involved in memory consolidation

Baylor College of Medicine
Peer-Reviewed Publication

How sleep enables the brain to strengthen memories is still not completely understood, but a new study published in Neuron reveals how astrocytes, brain cells known for supporting neurons and their functions, can directly regulate brain circuits involved in memory consolidation.

Journal: Neuron