Cooperative motor proteins found to kill cancer cells when dual-inhibited
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Jan-2026 19:11 ET (15-Jan-2026 00:11 GMT/UTC)
UOsaka and MIT scientists revealed that the motor proteins KIF18A and CENP-E work together to align chromosomes during mitosis. Cancer cells with reduced CENP-E levels are especially sensitive to KIF18A inhibition, and dual inhibition of both proteins leads to efficient cell death. The discovery offers new insights into chromosome mechanics and a potential strategy for targeted cancer therapy.
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