18-Jun-2025
南京中医药大学曹鹏团队揭示紫苏叶细胞外囊泡样颗粒跨界递送miRNA治疗银屑病的机制
ResearchPeer-Reviewed Publication
近期,南京中医药大学曹鹏教授团队围绕植物来源细胞外囊泡样颗粒在炎症性皮肤病治疗中的应用潜力开展深入研究,提出了一种基于紫苏叶细胞外囊泡样颗粒(Perilla Leaf-Derived Extracellular Vesicle-like Particles, PLEVPs)的新型治疗银屑病策略,并构建了“药用植物筛选—成分与功能解析—机制验证—动物模型评估”的完整科研闭环。团队研究发现,PLEVPs可通过递送功能性miRNA pab-miR396a-5p,精准调控IL-17信号通路,有效缓解银屑病相关的炎症反应与角质形成细胞过度增殖,展现出良好的局部治疗效果和转化潜力。相关成果以“Perilla frutescens Leaf-Derived Extracellular Vesicle-Like Particles Carry Pab-miR-396a-5p to Alleviate Psoriasis by Modulating IL-17 Signaling”为题,已在线发表在国际期刊《Research》上。
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- Research
- Funder
- National Key Research and Development Program of China, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, Jiangsu Provincial Medical Innovation Center, “New High School 20 Items” Project of Jinan, Taishan Scholars Program, Innovation Projects of State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture