Tokyo, Japan – Researchers from Tokyo Metropolitan University have developed a suite of algorithms to automate the counting of sister chromatid exchanges (SCE) in chromosomes under the microscope. Conventional analysis requires trained personnel and time, with variability between different people. The team’s machine-learning-based algorithm boasts an accuracy of 84% and gives a more objective measurement. This could be a game changer for diagnosing disorders tied to abnormal numbers of SCEs, like Bloom syndrome.

445 million years ago, life on our planet was forever changed. During a geological blink of an eye, glaciers formed over the supercontinent Gondwana, drying out many of the vast, shallow seas like a sponge and giving us an ‘icehouse climate’ that, together with radically changed ocean chemistry, ultimately caused the extinction of about 85% of all marine species – the majority of life on Earth.

In a new Science Advances study, researchers from the Okinawa Institute of Science and Technology (OIST) have now proved that from this biological havoc, known as the Late Ordovician Mass Extinction (LOME), came an unprecedented richness of vertebrate life. During the upheaval, one group came to dominate all others, putting life on the path to what we know it as today: jawed vertebrates.

We've all been there…

You know you need to make that complaint phone call, but you cannot bring yourself to dial. Or there is a project your demanding boss assigned, and even though you know you should start, you just…can't. You’re stuck at the starting line, caught in that all-too-familiar sense of motivational paralysis.

Why is it so hard to just get started?

Now, scientists at Kyoto University's Institute for the Advanced Study of Human Biology (WPI-ASHBi) have discovered what's happening in the brain during these frustrating moments. The research team conducted research on macaque monkeys and identified a specific brain circuit that acts like a "motivation brake": a neural pathway connecting two brain regions (the ventral striatum and ventral pallidum) that kicks in when we are confronted with tasks that come with negative consequences. When the scientists temporarily disabled this circuit, the motivational brake released: tasks that were once avoided suddenly became approachable. This discovery may help explain why, for some people (such as those living with depression), starting even simple tasks can feel impossibly hard. By identifying the brain "switch" behind this motivational paralysis, researchers may be one step closer to developing new treatments that help people overcome this invisible barrier.

The research is led by Dr. Ken-ichi Amemori, Dr. Jungmin Oh, and Dr. Satoko Amemori, with Dr. Masahiko Takada (Professor, Center for Human Behavior Evolution Research; currently Professor Emeritus), Dr. Ken-ichi Inoue (Assistant Professor; currently Associate Professor at Nagoya City University), and Dr. Kei Kimura (Assistant Professor, Tohoku University). The findings of this study will be published online in Current Biology at 11:00 a.m. on January 9, 2026 (EST; January 10, 1:00 a.m. JST).

A record of repeated retreat of the West Antarctic Ice Sheet during the past warm climates has been identified by IODP Exp379 Scientists. By analyzing deep-sea sediments from the Amundsen Sea and tracing their geochemical signatures, the study shows that the ice sheet retreated far inland at least five times during the warm Pliocene Epoch. The findings highlight the ice sheet’s sensitivity to warming and its potential to drive future sea-level rise.

Solid oxide fuel cells (SOFCs) offer a clean alternative to fossil fuel-based power generation, but their high operating temperatures hinder widespread use. In a recent study, researchers from Japan developed ultra-thin, highly ordered samarium-doped cerium oxide electrolyte films that overcome the long-standing issue of grain boundary resistance, enabling efficient operation at much lower temperatures. Their design achieved record-setting oxide-ion conductivity and paves the way for safer, more affordable SOFCs for sustainable power generation.

Alzheimer’s disease (AD) is a serious neurodegenerative disease largely affecting older adults. Apart from age, it also shows sex-based differences, with women being more at risk. However, the origin of these differences remains unknown. While bone morphogenetic proteins (BMPs) play an important role in adult neurogenesis, their role in AD remains elusive. To address this, researchers have investigated sex-based differences and role of BMP signaling in neurogenesis in AD mice models, uncovering novel therapeutic targets

A new study has identified the first known gene in eggplant that provides resistance to begomoviruses, a group of plant viruses responsible for major crop losses worldwide. The research shows that virus-resistant plants accumulate far less viral DNA than susceptible plants, linked to a gene encoding an exonuclease involved in viral defense. This previously unknown resistance pathway could support the breeding of virus-resistant crops, strengthen food security, and reduce reliance on chemical pesticides.

Kyoto, Japan -- A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency partially depends on the usage of a codon, or sequence of three nucleotides, that matches the cellular pool of tRNA, key molecules in translation. Using rare codons that are poorly supported by the cellular tRNA pool tends to induce ribosome pausing and mRNA instability, often weakening the virus.

Yet many eukaryotic viruses use a codon pattern that deviates from their host's while still relying on the host's translation mechanism. Theoretically this mismatch should hinder viral mRNA translation, but these viruses may have found a way to alleviate this unfavorable translation condition during infection. To understand how this happens, an international team of researchers, including a team from Kyoto University, decided to investigate.

The team focused on the giant virus Acanthamoeba polyphaga mimivirus, or APMV. This virus has a genome rich in AT sequences but a GC content of only 28 percent, while the amoeba that hosts this virus has a GC content of 58 percent. To identify the dynamics of this viral infection, the researchers examined APMV-infected amoeba cells using a combination of sequencing methods, including Ribosome profiling to estimate the frequency of translation pausing and tRNA sequencing to determine tRNA composition.