A new tunable cell-sorting device with potential biomedical applications
Peer-Reviewed Publication
Updates every hour. Last Updated: 5-Dec-2025 12:11 ET (5-Dec-2025 17:11 GMT/UTC)
Poly(N-isopropylacrylamide) (PNIPAM) hydrogel undergoes significant but precise changes in size between 20 and 40 °C, making it an excellent candidate for use in variable-size deterministic lateral displacement (DLD) array devices. Researchers from Science Tokyo have built a tunable DLD cell-sorting platform and verified its ability to sort cancer cells of defined sizes from blood samples. This platform could offer high-resolution size-based cell sorting for a wide variety of biomedical applications
There is an important and unresolved tension in cosmology regarding the rate at which the universe is expanding, and resolving this could reveal new physics. Astronomers constantly seek new ways to measure this expansion in case there may be unknown errors in data from conventional markers such as supernovae. Recently, researchers including those from the University of Tokyo measured the expansion of the universe using novel techniques and new data from the latest telescopes. Their method exploits the way light from extremely distant objects takes multiple pathways to get to us. Differences in these pathways help improve models on what happens at the largest cosmological scales, including expansion.
Silver-based atomic switches that create stable electrical connections between individual molecules and electrodes have been developed by researchers from Japan, addressing a key challenge in wiring molecular electronics. The switch operates by forming and breaking silver atomic filaments when a voltage is applied and reversed, corresponding to the “on” and “off” states. This method enables the scalable integration of molecular components, paving the way for ultra-compact and energy-efficient circuits built from single molecules.
Smart polymers change their properties in response to temperature, stress, or other stimuli, making them useful in drug delivery and soft robotics. But a major hurdle has been understanding how they behave when flowing or being stretched—conditions they face in real-world use. Now, researchers from Tokyo University of Science have developed a custom rheo-impedance device that provides the first look at these details, paving the way for more reliable and responsive smart materials.
A recent study explores how Japanese learners of French produce ambiguous speech errors. Using a specialized assessment tool, researchers found that many mistakes once considered purely “phonetic” may actually be rooted in morpholexical misunderstanding, and vice-versa. The findings offer teachers valuable guidance for improving pronunciation pedagogy and error correction. This work opens new possibilities for assessing ambiguity in second-language speech and better understanding the interplay between sound and meaning in learning French.
Kyoto, Japan -- "Why are we here?" is humanity's most fundamental and persistent question. Tracing the origins of the elements is a direct attempt to answer this at its deepest level. We know many elements are created inside stars and supernovae, which then cast them out into the universe, yet the origins of some key elements has remained a mystery.
Chlorine and potassium, both odd-Z elements -- possessing an odd number of protons -- are essential to life and planet formation. According to current theoretical models, stars produce only about one-tenth the amount of these elements observed in the universe, a discrepancy that has long puzzled astrophysicists.
This inspired a group of researchers at Kyoto University and Meiji University to examine supernova remnants for traces of these elements. Using XRISM -- short for X-Ray Imaging and Spectroscopy Mission, an X-ray satellite launched by JAXA in 2023 -- the team was able to perform high-resolution X-ray spectroscopic observations of the Cassiopeia A supernova remnant within the Milky Way.