Can brain damage in neuromyelitis optica spectrum disorder keep progressing silently?
Peer-Reviewed Publication
Updates every hour. Last Updated: 19-Jun-2026 00:15 ET (19-Jun-2026 04:15 GMT/UTC)
Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune neurodegenerative condition, has traditionally been viewed as a disease in which neurological damage occurs mainly during inflammatory relapses or ‘attacks.’ Now, an MRI study by researchers from Japan and Germany suggests that silent neurodegeneration may continue even during periods without attacks, indicating that monitoring brain atrophy and cognitive function is important even in clinically stable patients with NMOSD.
Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, between fibres—to reach the areas where they form neural circuits in the brain cortex.
In a new study published in Nature, researchers at Kyoto University's Institute for Integrated Cell-Material Sciences (WPI-iCeMS) and their collaborators report that this journey causes widespread DNA damage in neurons, resulting in double-strand breaks where both strands of the double helix are completely severed. While this is the most severe type of DNA damage—capable of causing mutations and cell death—the team surprisingly found that it is a normal, routine feature of brain cortex formation, and a healthy brain quickly repairs it before harm occurs.
Cells have surface receptors that couple to proteins and other molecules to initiate or inhibit certain behaviors. Typically, the number of these receptors increases as the cell matures, but researchers have now identified that one receptor influences cell behavior much earlier than previously thought and appears to help trigger the cell differentiation process to form neurons.
Astronomers using the Atacama Large Millimeter/submillimeter Array (ALMA), with help from a ‘natural telescope’ formed by gravity, have identified the source of a neutrino burst. The team expected a supermassive black hole to be the engine driving the remarkably bright galaxy. Instead, the team found that the galaxy was driven by vigorous star formation. This result provides important observational evidence to help explain the mysterious origin of cosmic neutrinos.
Continuous consumption of foods containing heat-inactivated Lactiplantibacillus pentosus can help reduce gum bleeding, report researchers from Institute of Science Tokyo. These postbiotic foods can improve inflammatory conditions and enhance gum health in adults with mild gingivitis. The study suggested that these postbiotic foods offer a simple and practical way to support oral health in daily life without altering oral care habits. The findings also aid in the prevention of early-stage periodontal disease.
The National Institute of Information and Communications Technology (NICT), Sharp Corporation, Mitsubishi Chemical Corporation, and TECHLAB Co., Ltd. jointly reduced the total weight of a planar antenna for NTN (Non-Terrestrial Network) applications by 47% (from 5.5 kg to 2.9 kg) through a new heat dissipation device design.
This was achieved by integrating a CFRP heat dissipation device using a composite material combining carbon fiber prepreg and graphite sheet into the NTN planar antenna. The required electrical performance of the planar antenna was also confirmed. In addition, operation including the modem was confirmed as a satellite communication user terminal.
The achievement greatly expands the range of mobility platforms on which the terminal can be deployed, including drones and vehicles. It is expected to support the establishment of communication links in mountainous areas and disaster-affected regions, real-time transmission of location information from various types of mobility, and future applications such as autonomous driving, thereby representing a major step toward the realization of NTN.