A scientific review published today in the NEJM Evidence journal, coordinated by the D’Or Institute for Research and Education (IDOR), evaluated outcomes of adults with community-acquired pneumonia (CAP) admitted to intensive care units (ICUs) in middle-income countries.

In contrast to high-income countries, where mortality ranges from 16% to 26%, the study found significantly higher rates in the countries analyzed. The work brought together 52 studies and approximately 48,707 patients, revealing an overall mortality rate of 37.1%, which increased to 59.3% among patients requiring respiratory support.

Scientists from the Alliance of Bioversity International and the International Center for Tropical Agriculture (CIAT), together with Hacienda San José (HSJ) in the department of Vichada, developed a pioneering methodology to estimate greenhouse gas emissions associated with bovine genetic resources—a component that had so far remained invisible in livestock carbon footprint analyses. 

The study, published in the prestigious journal The International Journal of Life Cycle Assessment, demonstrates that the Short-Cycle Nelore breed used at HSJ emits up to 17% fewer greenhouse gases per kilogram of live weight than conventional Brahman cattle, due to its accelerated growth and reproductive performance. 

This finding complements the study published in 2022 by the same team, which concluded that the integrated management of improved pastures in tropical savannas can offset up to three times the emissions generated by cattle. 

Experiments with rodents show that metabolic dysfunction is “transmitted” to offspring through molecules present in sperm, causing them to become pre-diabetic. This phenomenon is reversible through weight loss before conception.

Researchers from the universities of São Paulo and Oxford show that the duration of the disorder and severity of symptoms are associated with differences in functional brain connections, which may pave the way for personalized treatments.

Brazilian researchers have discovered why the guardian of the genome, p53, is uniquely prone to structural failure compared to its more robust relatives. The study identifies molecular gaps and structural frustration that trigger p53 cancer-linked aggregation, revealing how the protein sequence balances flexibility with vulnerability. These findings, stemming from over twenty years of research, provide a new roadmap for next-generation cancer therapies focused on stabilizing this critical protein.

The study identified cultivars that maintain high productivity and resilience against attacks from the disease, paving the way for more sustainable cultivation in the region. An increase in production of up to 32% was observed in varieties with high adaptive capacity and strengthened by nutrition that ensures vigor and resistance, compared to varieties more susceptible to the fungus.