RNA design is central to next-generation therapeutics, yet identifying sequences that reliably fold into desired structures remains a major computational challenge, often constrained by high cost and time. A new study from Keio University explores the use of factorization machine with quadratic-optimization annealing (FMQA) for RNA inverse folding, while also examining how different encoding strategies may influence artificial intelligence (AI)-driven design performance, revealing an underexplored dimension of biomolecular engineering.

Chinese scientists have identified five major fundamental scientific questions for extreme complex geological disaster chains: “disaster gestation through multi-sphere interactions, disaster regulation by multi-interface control, disaster propulsion by multi-dynamic coupling, disaster initiation by extreme events, and disaster amplification through multi-disaster chain interactions.” They further reveal the core characteristics of disaster chains from the three dimensions of time, space, and human activities, and construct a coherent “mechanism–prediction–prevention and control” research framework.

A new study published in the Proceedings of the National Academy of Sciences (PNAS) finds that individual human neurons are capable of significantly more complex computations than those of other mammals, offering a fresh view to what makes the human brain unique.

Research led by the Singapore University of Technology and Design finds that comfort in Singapore homes depends not only on air-conditioning and building design, but also on airflow, daily routines and how families share their living spaces.