We have proposed a new therapeutic effect of CAR-T-cell therapy through a lymphoma case treated with bispecific antibody (BsAb). Memory-formed T cells had been developed in the body after CAR-T-cell therapy. Interestingly, bystander CAR-negative CD8⁺ T cells in the CAR-T-cell product successfully expanded in periphery and lymph node, and mostly propagated after treatment with BsAb, which resulted in complete remission. Therefore, such sequential approach using CAR-T/BsAb might have a potential to further enhance antitumor effects.

What happens when things combine? This question lies at the heart of the Borell-Brascamp-Lieb inequality (BBL), a mathematical relation widely applied across many fields of mathematics, science and beyond. Now, researchers from the Okinawa Institute of Science and Technology (OIST), University of Tokyo and University of Florence have provided a new proof for this powerful inequality, taking an unconventional approach based on heat and diffusion equations.

Researchers at the University of Chicago Pritzker School of Molecular Engineering and their collaborators have developed polymer-based nanoparticles that self-assemble with a temperature shift, offering a simple method for delivering protein-based medicines and vaccines.

Renewable energy is growing, but it’s often remote from EV charging stations. Delivering clean energy through the current grid is limited by grid congestion. Without grid upgrades, EVs will still rely on fossil fuel-generated energy. Smart, targeted upgrades could solve grid congestion to unlock EVs’ potential.