Rethinking coupling methods for more sustainable organic synthesis
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Jul-2025 07:10 ET (26-Jul-2025 11:10 GMT/UTC)
Coupling reactions are essential in the synthesis of pharmaceuticals, agrochemicals, and advanced materials, but traditional methods often rely on costly and environmentally taxing transition metal catalysts. Now, researchers from Japan have reviewed emerging transition metal-free alternatives that align better with green chemistry principles. Their study highlights hypervalent iodine-mediated coupling, a strategy that enables selective bond formation without rare metals. By leveraging diaryliodonium salts, this approach can greatly enhance efficiency and reduce waste in coupling reactions.
Nanoplastics are an increasing threat to the ecosystem; however, their mobility in the soil is still underexplored. Against this backdrop, researchers from Waseda University and the National Institute of Advanced Industrial Science and Technology investigated the adsorption and aggregation behavior of nanoplastics in different types of soil under different pH conditions. The study offers new perspectives on the migration and environmental interactions of nanoplastics, while broadening our knowledge of pollution dynamics and soil contamination processes.
Sorghum is one of the world’s oldest grains and possesses many traits that can benefit food security, climate resilience, and biodiversity. However, the mechanisms behind these traits have long remained a mystery to researchers, which has hindered efficient cultivation. Now, a new technique and a biobank - developed in collaboration with the University of Copenhagen - have made research and breeding possible at an unprecedented pace, paving the way to an effective crop in both the Global North and South.
A recent study has used advanced techniques to uncover the role of ultraviolet (UV) light in activating peracetic acid (PAA) to generate powerful radicals, essential for water treatment. By combining in-situ electron paramagnetic resonance (EPR) with density functional theory (DFT) calculation, the researchers identified and analyzed the types and concentrations of radicals produced under different UV wavelengths (185, 254, and 365 nm). The results show that UV light at different wavelengths influences the type and concentration of formed radicals. The study provides new insights into how PAA-based advanced oxidation processes (AOPs) work based on the key radicals identification, offering a solid foundation for optimizing UV-based water purification technologies and potentially expanding their application in environmental remediation areas.
Researchers analyzed trade-related risks to energy security across 1,092 scenarios for cutting carbon emissions by 2060. They found that swapping out dependence on imported fossil fuels for increased dependence on critical minerals for clean energy would improve security for most nations – including the U.S., if it cultivates new trade partners.
Researchers have reviewed metamaterials to emulate Schrödinger dynamics, bridging classical wave physics and quantum phenomena. Such analog enables robust wave manipulation and explores quantum behaviors beyond electronic systems, promising breakthroughs in imaging, sensing, and energy technologies.