Just as a computer’s operating system can be rewritten after a major update, dengue infection can ‘re-programme’ the body’s immune system, leaving a long-lasting genetic imprint that influences how people respond to future infections—an effect not seen with vaccination. This finding from a new study sheds light on the mechanics of dengue disease progression and vaccine action, filling an important knowledge gap on how even imperfect vaccines can be used safely.

High-grade serous carcinoma is a rare diagnosis in cervical biopsies. Cervical serous carcinoma is no longer recognized as a primary cervical tumor in the 2020 World Health Organization classification. This study aimed to characterize the clinicopathologic, immunohistochemical, and molecular features of high-grade serous carcinoma identified in cervical or endocervical biopsies, to assess tumor origin and ensure accurate classification.

A new study reveals that frailty-associated gut dysbiosis significantly elevates the risk of gastrointestinal complications following intracorporeal urinary diversion for bladder cancer. Despite short-term antibiotic prophylaxis, residual intra-abdominal bacteria and fungi—particularly Enterococcus and Enterobacter—were strongly associated with postoperative ileus and infections. The findings underscore frailty as a key determinant of surgical outcomes and point toward microbiota-based management strategies to improve recovery and reduce complications.