Study identifies PARG as a new target to enhance chemotherapy in colorectal cancer
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Updates every hour. Last Updated: 3-Jun-2026 19:15 ET (3-Jun-2026 23:15 GMT/UTC)
Cancer immunotherapy has revolutionized cancer care, yet most patients still fail to respond. A new study reveals how cancer cells package the immune-suppressing protein PD-L1 into tiny extracellular vesicles, undermining immunotherapy’s effectiveness. Remarkably, the researchers identify a common class of cholesterol-lowering drugs—statins—as powerful inhibitors of this process. By uncovering a hidden mechanism of immune resistance and a readily available way to block it, the study opens new avenues for improving cancer immunotherapy outcomes.
Middle-aged and older adults — particularly women — who are naturally more active in the evenings may have worse cardiovascular health, as measured by the American Heart Association’s Life’s Essential 8 metric, in comparison to peers without a strong morning or evening preference.
A new scientific statement from the American Heart Association and endorsed by the American College of Obstetricians & Gynecologists details risk factors for pregnancy-related stroke and offers suggestions for stroke prevention, rapid diagnosis, timely treatment and recovery during pregnancy and postpartum.