A research paper by scientists at Wenzhou Medical University developes a mannose-modified pH/glutathione (GSH) dual-responsive nano-delivery system (MPP@IKE-aPD-1/diABZI) that synergistically activates ferroptosis and immune responses to achieve efficient antitumor therapy.

The University of East London (UEL) is leading a major new neuroscience research project in partnership with The Queen’s Reading Room, founded by Her Majesty Queen Camilla, and The Bentley Foundation. Headed by Professor Sam Wass,  Director of the Institute for the Science of Early Years and Youth (ISEY) at UEL, the laboratory-controlled study will examine the psychological and physiological impact of shared reading and book clubs, exploring how reading together can reduce stress, strengthen social bonds and improve mental wellbeing.

Building on The Queen’s Reading Room’s groundbreaking 2024 study which found that just five minutes of reading can reduce stress by nearly 20% and lower loneliness by up to 70%, the research will apply rigorous neuroscientific methods to understand the wider health and social benefits of communal reading.

CAMBRIDGE, Mass., January 23, 2026 --- Insilico Medicine (3696.HK), a clinical-stage drug discovery and development company driven by generative artificial intelligence (AI), today announced that ISM8969, an orally available NLRP3 inhibitor targeting inflammation and neurodegenerative disorders, has recently received investigational new drug (IND) clearance from the U.S. Food and Drug Administration (FDA), intended for the treatment of Parkinson’s Disease. 

Secondary lymphedema, a chronic condition caused by lymph node removal during cancer surgery, leads to swelling, pain, and reduced mobility with limited treatment options. In a recent study, researchers from Japan developed a centrifugal cell stacking technique to create artificial lymphatic tissues that can restore lymphatic flow. When transplanted into mice, CeLyTs form functional lymph node-like structures that reduce swelling and promote lymph flow, offering a promising therapeutic strategy for lymphedema.

This article summarizes metabolic reprogramming in prostate cancer (PCa). Early PCa relies more on glycolysis. castration-resistant prostate cancer (CRPC) enhances glucose metabolism, shifts glutaminase isoform for efficient glutamine use, and upregulates lipid metabolism via androgen receptor. Targeting these pathways offers new therapeutic strategies for PCa, especially CRPC.

Large language models (LLMs) play a key role in advancing intelligent healthcare. While LLMs are increasingly applied in medical fields such as disease screening, diagnostic assistance, and health management, there are no evidence-based guidelines for assessing their effectiveness in healthcare. Now, researchers have developed a consensus that provides a systematic and evidence-based evaluation framework to assess effectiveness of LLMs in medical applications. The framework includes scientific evaluation metrics and procedures, providing guidance for model evaluators.

Current guidelines lack clear, consistent recommendations on liver-beneficial exercise for metabolic dysfunction-associated steatotic liver disease. Analyzing 24 randomized controlled trials via Bayesian network and dose-response network meta-analyses, a new study confirms a nonlinear dose-response relationship between exercise and hepatic steatosis. It identifies key dose thresholds: 460 (minimum), 630 (cost-effective), and 850 MET-min/week (plateau), and highlights that combined aerobic-resistance exercise offers both efficacy and dose advantages, emphasizing tailored prescriptions based on patient heterogeneity, preferences, and conditions.