In the human body, stem cells process genetic information in an exceptionally reliable and very fast manner.  To do this, they specifically access certain sections of the DNA in the cell nucleus. Researchers at Karlsruhe Institute of Technology (KIT) have investigated how the DNA-based information processing system works. Their results show that this process is comparable to processes in modern computers and could therefore serve as a model for new types of DNA-based computer chips. Published in “Annals of the New York Academy of Sciences.” (DOI: 10.1111/nyas.15415)

Patients who suffer from chronic conditions often require continuous injections of drugs, which is quite painful and often inconvenient. To address this, researchers from South Korea have developed new wearable microneedles which are inspired by bee stings. These electrospun web microneedles (EW-MNs) deliver drugs continuously through the skin without causing discomfort. In animal models, the system enhanced drug absorption while ensuring comfort—offering a safer and convenient alternative to conventional needle systems.

Adenomyosis affects up to one-third of women of reproductive age and is linked to pain, heavy bleeding, and infertility. Researchers from Jiaxing University and Tongji University have developed a new laboratory “assembloid” model that mimics uterine tissue, published in SCIENCE CHINA Life Sciences. The model reveals that abnormal stromal cell subgroups may disrupt BMP and WNT signaling pathways, driving disease progression. This work provides a valuable tool for studying adenomyosis mechanisms and developing new treatments.

Chikungunya is a vector-borne disease that affects both adults and children. While global efforts are ongoing to tackle chikungunya in adults, progress in addressing pediatric chikungunya remains inadequate. To shed light on this, researchers have investigated the presentation of pediatric chikungunya and proposed multipronged approaches to diagnose, prevent, and manage this disease. These insights may help clinicians, researchers, and policymakers to develop effective measures to tackle pediatric chikungunya.