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Medicine & Health

Updates every hour. Last Updated: 31-Dec-2025 08:11 ET (31-Dec-2025 13:11 GMT/UTC)

FDA clears UCLA heart tissue regeneration drug AD-NP1 for clinical trials

University of California - Los Angeles
Business Announcement

Internal organ tissues often don’t heal after illness or injury and lose some function, such as the heart after a heart attack. UCLA cardiologists have identified a protein that interferes with healing. Funded entirely by federal and state grants, the researchers developed a drug to block this protein and promote tissue regeneration. The FDA has now granted approval to begin Phase I clinical trials of the first-in-class drug for tissue repair, called AD-NP1, in humans.

Researchers lead $3.7 million study to shed light on perimenopause and psychosis

Michigan State University
Grant and Award Announcement

Researchers from Michigan State University’s Department of Psychology are examining the understudied period of perimenopause and its potential impacts on mental health thanks to a $3.7 million grant from the National Institute of Mental Health.

Improving heart health in young adulthood reduces risk for cardiovascular disease in later life

Boston University School of Medicine
Peer-Reviewed Publication

Despite progress in past decades to reduce the burden of cardiovascular disease (CVD), it remains the leading cause of death in the U.S. and worldwide. Data within the past 10 years indicate deceleration and reversal of declines in CVD morbidity and mortality. These trends may be further worsened by the prevalence of low heart health, particularly among young adults.

A new study by researchers from Boston University Chobanian & Avedisian School of Medicine has found that among young adults, unfavorable patterns of heart health through young adulthood were associated with increased risk for CVD later in life.

Journal: JAMA Network Open

UCLA Health study finds inhalers for asthma and COPD drive significant greenhouse gas emissions

University of California - Los Angeles Health Sciences
Peer-Reviewed Publication

Inhalers are the frontline treatment for asthma and COPD, but they come with a steep environmental cost, according to a new UCLA Health study — the largest to date quantifying inhaler-related emissions in the United States.

Journal: JAMA

A surgical handover system for patient physiology and safety

JAMA Network
Peer-Reviewed Publication

About The Study: In this cohort study, implementation of the sickest patients first (SIPS) surgical handover system (introduction, situation, background, assessment, recommendation; prioritize; summarize) was associated with improvements in handover quality, patient physiology, and staff perceptions of safety without prolonging handover meetings.

Journal: JAMA Network Open

Cardiovascular health changes in young adults and risk of later-life cardiovascular disease

JAMA Network
Peer-Reviewed Publication

About The Study: In this prospective cohort study of young adults, unfavorable patterns of cardiovascular health (CVH) change through young adulthood were associated with marked elevations in risk for incident cardiovascular disease (CVD). These data suggest that achieving and maintaining high CVH throughout young adulthood through strategies of primordial prevention are important for prevention of later-life CVD.

Journal: JAMA Network Open

Sperm microRNAs: Key regulators of the paternal transmission of exercise capacity

Nanjing University School of Life Sciences
Peer-Reviewed Publication

Researchers from Nanjing University and Nanjing Medical University have identified sperm microRNAs as key messengers that transmit the benefits of paternal exercise to the next generation. Published in Cell Metabolism, the study shows that offspring of exercise-trained fathers inherit improved exercise endurance and metabolic health. Mechanistically, sperm microRNAs from exercised fathers suppress NCoR1 in early embryos, reprogramming gene networks to enhance mitochondrial biogenesis and glucose metabolism. These findings establish a PGC-1α–sperm microRNA–NCoR1 axis for intergenerational inheritance and suggest that paternal exercise before conception may offer a simple, cost-effective way to improve offspring health and help break the cycle of obesity and chronic disease.

Journal: Cell Metabolism