Weill Cornell Medicine investigators have developed a new AI-based method to assess patients with a form of blood cancer called myelodysplastic neoplasms. The method, published June 30 in Leukemia, compares the physical locations and morphometric (size and shape) characteristics of every hematopoietic cell in the patient’s bone marrow sample with those in healthy bone marrow, to generate a score that reflects disease severity.

Significant advances have been made in the development of patient-derived tumor “organoids” for preclinical research, in two new studies led by Weill Cornell Medicine investigators. The advances represent progress in precision medicine and point to the more routine use of tumor organoids as models for evaluating and optimizing cancer treatments.

Dubbed PATTY, the tool corrects hidden bias in a widely used genomics method, helping scientists distinguish true biological discoveries from false leads.

Genetic adaptations that helped neotropical manakins detect and digest fruit may have laid the foundation for the evolution of elaborate courtship displays and vivid plumage observed in manakins. An international research team, including researchers from Institute of Science Tokyo, Japan, combined genomic, functional, and evolutionary analyses to show that changes in taste perception and digestion preceded the emergence of these vibrant traits—revealing how simple physiological changes could drive behavioral evolution and biodiversity.

A review article by a University of Nebraska Medical Center research team underscores and describes how altering fundamental brain development processes can be detrimental for the developing baby.