MDMA psychiatric applications synthesized: Comprehensive review examines PTSD treatment and emerging therapeutic indications
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-Jan-2026 16:11 ET (1-Jan-2026 21:11 GMT/UTC)
A comprehensive peer-reviewed invited review published in Psychedelics examines the therapeutic potential of MDMA across psychiatric conditions, synthesizing evidence from PTSD trials to emerging applications in autism and eating disorders. The authors identify gut-brain axis mechanisms underlying resilience enhancement while addressing critical safety considerations including hyponatremia and neurotoxicity risks. This synthesis provides clinicians and researchers with an integrated framework for understanding MDMA-assisted therapy as regulatory decisions evolve.
The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. We’re talking about the Maillard reaction, where sugars react with protein to form brown, sticky compounds in a process called glycation. Glycation is increasingly suspected to be a hidden driver of obesity, diabetes and accelerated aging. Researchers in the Kapahi lab have found a way to tame it in mice by feeding them a combination of glycation-lowering compounds.
The research team led by Dr. Byung Chul Lee at the Bionics Research Center of the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh), in collaboration with Prof. Jae-Woong Jeong at KAIST (President Kwang-Hyung Lee), Prof. Whal Lee at Seoul National University Hospital (Director Young-Tae Kim), and Prof. Pierre T. Khuri-Yakub at Stanford University (President Jonathan Levin), announced the development of a silicon-based disposable eco-friendly ultrasound patch. This achievement marks the first realization of superior performance beyond conventional high-cost lead-based ultrasound transducers without using lead at all.
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