WCM investigators empowering cancer researchers with AI
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jun-2026 14:16 ET (16-Jun-2026 18:16 GMT/UTC)
A team of Weill Cornell Medicine investigators is working to cross-train the next generation of cancer researchers in cancer biology and the use of artificial intelligence tools for research.
A new technology from TU Wien could revolutionize how drugs are delivered in the body: instead of distributing medication systemically, it enables precise, on-demand release exactly where it is needed. By combining electronic ion pumps with “click-to-release” chemistry, researchers can now control the timing and dosage of even large biomolecules with unprecedented accuracy. The approach promises more effective treatments with significantly fewer side effects, particularly for diseases such as cancer.
Mitochondrial dysfunction is seen in many cardiac disorders. Understanding mitochondrial quality control (MQC) can help reduce dysfunction and improve outcomes for patients. Researchers have examined key regulatory proteins involved in MQC and how their functions are altered by the cellular microenvironment of the heart muscle. They also describe some promising new therapies that target the molecular components of MQC and restore proper mitochondrial function to damaged heart tissue.
Vaccines rely on adjuvants to enhance immune protection, but these often cause reactogenicity, such as swelling or fever. Challenging the long-held assumption that these effects are inseparable, researchers from Japan have shown that vaccine efficacy and reactogenicity are driven by distinct immune pathways. Their findings reveal specific roles for IL-1α and IL-1β in controlling these responses, opening new possibilities for designing vaccines that maintain strong immunity while minimizing adverse effects.
Recently, a significant study conducted collaboratively by multiple hospitals in Shanghai was published in the prestigious journal SCIENCE CHINA Life Sciences. This work uncovers for the first time that ovarian cancer drives tumor growth and metastasis by secreting IL-1β-enriched extracellular vesicles (EVs), which activate the NF-κB signaling pathway in adipose-derived stem cells (ADSCs), thereby inducing adipose tissue senescence and associated metabolic disorders. The team has identified two targeted intervention strategies: the senolytic combination of dasatinib and quercetin, or the natural NF-κB inhibitor resveratrol. Both approaches markedly eliminate senescent ADSCs, ameliorate metabolic abnormalities, and suppress ovarian cancer progression. This study provides novel insights into treating ovarian cancer by modulating the tumor microenvironment (TME) and targeting senescent cells, and underscores the translational potential of natural compounds including quercetin and resveratrol in clinical applications.
A team led by Professor Julia Beatty, Chair Professor of Veterinary Medicine and Infectious Diseases at Jockey Club College of Veterinary Medicine and Life Sciences of City University of Hong Kong (CityUHK), recently published a review in the prestigious journal Nature Reviews Cancer, exploring how feline tumour viruses offer vital insights into human oncology and viral carcinogenesis from a comparative oncology perspective.