ROS serve as crucial mediators of redox homeostasis, playing decisive roles in diverse pathological processes. While inorganic sonosensitizers for SDT represent significant advances in ROS-based therapeutics, developing US-responsive sonosensitizers with optimal biocompatibility, and initiating innovative treatment strategies remains a substantial translational challenge. In this work, researchers demonstrate that FeOOH nanorods function as exceptional tribocatalysts capable of efficiently converting vibrational mechanical energy into therapeutic effects through sono-tribocatalytic activation.

A research paper recently published in Science China Life Sciences describes a genome-wide CRISPR/Cas9 knockout screen performed in bovine cells, aimed at identifying host factors involved in Bovine Parainfluenza Virus Type 3 (BPIV3) infection. Through this screen, researchers identified several key host factors essential for BPIV3 infection, including the sialic acid transporter SLC35A1 and the Sm-like protein LSM12. Subsequent mechanistic analyses further reveal that these factors exert critical roles at distinct stages of the BPIV3 entry process.

Scientists at Gladstone Institutes reveal why some rare individuals keep HIV under control even after stopping antiretroviral therapy—and in doing so, uncover possible new paths toward long-term remission that could include the common diabetes drug, metformin.