The world’s healthiest countries aren’t the richest, according to new study
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Updates every hour. Last Updated: 13-Jan-2026 18:11 ET (13-Jan-2026 23:11 GMT/UTC)
Using human-induced pluripotent stem cell-derived kidney organoids, researchers from Science Tokyo uncovered how abnormal Hippo signaling drives fibrosis in nephronophthisis, a genetic kidney disorder caused by NPHP1 deficiency. Confirming their discovery, the team demonstrated that inhibiting the Hippo signaling pathway effectively suppresses fibrosis in kidney tissue. The study highlights the potential of organoid-based disease models for elucidating disease mechanisms while offering a new therapeutic target for nephronophthisis.
Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published in Nature Genetics by researchers at Karolinska Institutet, among others.
An elevated blood glucose level one hour after the oral glucose tolerance test (OGTT) signals a critical metabolic state – even before prediabetes. Affected individuals respond particularly well to lifestyle interventions. This value could become a new clinically relevant biomarker – and enable more targeted, earlier prevention of type 2 diabetes. This is the conclusion reached by a team from the University of Tübingen, Helmholtz Munich and the German Center for Diabetes Research (DZD). This research, conducted in cooperation with Prof. Michael Bergman from New York University, has now been published in Metabolism.
The time of eating influences the lipid metabolism in our body. A study conducted at the German Center for Diabetes Research (DZD) and the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) shows: Eating earlier in the day leads to measurable changes in fat metabolism, as compared to a later eating window with the same calorie intake and nutrient composition.The time of eating influences the lipid metabolism in our body. A study conducted at the German Center for Diabetes Research (DZD) and the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) shows: Eating earlier in the day leads to measurable changes in fat metabolism, as compared to a later eating window with the same calorie intake and nutrient composition.