Historically, cerebral palsy (CP) was linked largely to events at birth, including prematurity or temporary loss of oxygen to the brain, but research over the past decade has suggested that genetic factors contribute to CP in many children. In a study publishing in the Cell Press journal American Journal of Human Genetics on September 3, researchers report that only 89 of the 515 genes previously linked to CP have a statistically significant association with the condition. They suggest that instead of viewing CP as a single disease with genetic causes, it may be better described as a collection of symptoms that can occur in many different conditions as a result of both genetic variants and environmental factors. 

Neuro-oncology, neurosurgery and nuclear medicine physicians from Ann & Robert H. Lurie Children’s Hospital of Chicago, in collaboration with Cerenome, Inc., launched the first clinical trial in children of radiotherapy called Rhenium-186 Nanoliposome (¹⁸⁶RNL), which is injected directly into the brain tumor through a catheter with hopes of providing minimal exposure to the surrounding healthy tissue. Children with recurrent high grade glioma (HGG) and ependymoma who have exhausted the standard of care options might be eligible to participate.

Researchers at the Marshall University Joan C. Edwards School of Medicine have identified a cellular signaling pathway in fat cells that may play an important role in the development of atherosclerosis, offering a potential new target for treating the disease. 

 

With a $37 million investment from the Starr Foundation, Brown University and Brown University Health will launch a new partnership to accelerate breakthroughs in aging research, clinical trials and patient treatments.

A team of researchers from INRAE, Inserm, Sorbonne Paris Nord University, Université Paris Cité and the CNAM has published the first study exploring the association between eating jetlag and the risk of cardiovascular disease. Eating jetlag refers to the difference in the timing of meals between weekdays—when mealtimes are often shaped by work schedules—and weekends or days off. This shift in eating patterns may disrupt the body’s biological rhythms and could have implications for cardiovascular health. Researchers analysed data from more than 100,000 participants in the NutriNet-Santé cohort over a 14-year follow-up period. Their findings, published in Communications Medicine, suggest that each additional hour of eating jetlag was associated with a 14% higher risk of cardiovascular disease in men and a 21% higher risk of coronary heart disease. They did not observe any significant association in women. These findings suggest that discrepancies in mealtimes between weekdays and weekends may play a role in the onset of cardiovascular disease.