Diazoacetic acid esters are important intermediates in drug and agrochemical synthesis, but their preparation typically requires hazardous diazomethane. Researchers from the Tokyo University of Science developed a safer method using a Michael addition-mediated azide-to-diazo conversion. By pretreating 2-azidoacrylic acid esters with a bulky phosphine followed by nucleophile addition, they produced β-heteroatom-substituted diazo esters without toxic precursors. This simpler approach offers a practical and flexible route to access diverse organonitrogen compounds.

In the years following the COVID-19 pandemic, an ideal vision of family life would have shown that parents are continuing to share in caregiving responsibilities and spending quality time with their children — dads, in particular. Many people hoped that the behavioral changes caused by lockdowns would persist, allowing dads more time and flexibility in the long term and ultimately reshaping how we view fatherhood in general. However, according to new research from University of Notre Dame anthropologist and fatherhood expert Lee Gettler, those fathering benefits have not outlasted the pandemic itself.