Integrin α3 (ITGA3) expression across breast cancer subtypes: Prognosis and therapeutic relevance
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2026 20:16 ET (29-Oct-2026 00:16 GMT/UTC)
Highlights
• Integrin alpha 3 (ITGA3) protein expression was detected in approximately 85% of breast cancer specimens by immunohistochemistry.
• ITGA3 expression was significantly higher in human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor(HR)-positive/HER2-negative breast cancer than in triple-negative breast cancer (TNBC).
• High ITGA3 protein expression was associated with shorter 5-year recurrence-free survival.
• ITGA3 alterations in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort were associated with worse relapse-free and overall survival.
• Integrin α3β1 represents a potential prognostic biomarker and therapeutic target warranting prospective validation.
A UCLA study found a connection between how quickly the brain ages and the bacteria and chemical byproducts found in the gut, offering a fresh clue into what drives brain aging long before symptoms appear.
A Reusable Catalyst for Antibiotic Removal
Sulfamethoxazole, a widely used antimicrobial, can persist in aquatic environments and pose risks to ecosystems and human health. Researchers led by Xuejiao Tang at Nankai University developed millimeter-scale magnetic carbon beads, designated CoNC@cPAN/rGO-800, to address the limited recoverability and metal-leaching concerns associated with powdered cobalt catalysts. The material combines a polyacrylonitrile carbon framework, reduced graphene oxide, and cobalt-containing active sites.
Porous Structure, Rapid Degradation
The beads were prepared from a cobalt-containing zeolitic imidazolate framework, polyacrylonitrile, and graphene oxide, followed by calcination under nitrogen at different temperatures. Microscopy, spectroscopy, diffraction, surface-area analysis, electrochemical measurements, and density functional theory calculations were used to characterize the material and assess its catalytic behavior. Under optimized conditions, 0.1 g L⁻¹ of catalyst and 0.1 g L⁻¹ of peroxymonosulfate removed 100% of 10 mg L⁻¹ sulfamethoxazole within 20 min at pH 7.
SHEA has published a new practical guide to help healthcare organizations build the business case for diagnostic stewardship. Published in Antimicrobial Stewardship & Healthcare Epidemiology (ASHE), the resource outlines five high-impact interventions and provides implementation strategies and financial models that hospitals can adapt to their own settings. The authors estimate that a representative 200-bed community hospital implementing all five interventions could realize approximately $2.5–$2.8 million in annual laboratory and clinical savings, with additional potential savings through improved quality metrics and reduced CMS penalties. The guide, developed by SHEA’s Diagnostic Stewardship Special Interest Group, demonstrates how diagnostic stewardship can simultaneously improve patient care, healthcare quality, and operational performance.