Two University of Virginia scientists have been elected to the prestigious American Academy of Arts & Sciences, a storied group founded during the Revolutionary War by John Adams, John Hancock and 60 other scholar-patriots to advance the public good.

Diazoacetic acid esters are important intermediates in drug and agrochemical synthesis, but their preparation typically requires hazardous diazomethane. Researchers from the Tokyo University of Science developed a safer method using a Michael addition-mediated azide-to-diazo conversion. By pretreating 2-azidoacrylic acid esters with a bulky phosphine followed by nucleophile addition, they produced β-heteroatom-substituted diazo esters without toxic precursors. This simpler approach offers a practical and flexible route to access diverse organonitrogen compounds.