BUFFALO, NY — September 16, 2026 — A new research paper was published in Volume 18 of Aging on August 28, 2026, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.”

Research shows that cirrhosis developed in 11.4% of patients after liver transplantation. Most cases reflected recurrence of the original liver disease, while de novo cirrhosis was most often associated with chronic rejection or metabolic dysfunction-associated steatohepatitis. Patients who developed cirrhosis after transplantation had lower 20-year survival than those who did not, underscoring the importance of lifelong surveillance for fibrosis progression after transplantation.

Neuropathic pain, caused by damage or dysfunction of the nerves, is often difficult to treat because medicines that reduce pain may also cause unwanted effects. Now, researchers have developed humanized antibodies that target Nav1.7, a sodium channel involved in pain signaling. The antibodies produced pain relief lasting at least 96 hours in rat models, without affecting normal pain responses, providing preclinical support for a potential long-acting treatment strategy for neuropathic pain. 

Researchers at City of Hope^®, one of the largest and most advanced cancer research and treatment organizations in the country, led the development of a new, investigational blood test that could detect pancreatic cancer at its earliest stages, when the disease is more treatable and potentially curable.

One reason pancreatic cancer remains so deadly is because it’s usually discovered late, after it has spread. A large, international study, published in Nature Medicine today, found that this liquid biopsy, called PANXEON*, was highly sensitive in detecting stage 1 and 2 pancreatic cancer and had a low rate of false positives. The experimental test was also able to identify high-grade dysplasia, a precancerous condition of the pancreas, potentially enabling intervention before cancer develops.

What's the price of climate-driven heat stress on worker producivity? A UC Davis study quantifies the cost.

Study reveals how specialised tendon cells respond to changes in their physical environment, opening new possibilities for future research into tendon health and repair 

Cytology tests are widely used for cancer screening, but diagnosis can be challenging when tumor and non-tumor cells look very similar. Researchers from Japan developed a machine learning system that identifies tumor cells based on their white-light scattering spectra. The approach achieved high diagnostic accuracy for mesothelioma and showed potential for distinguishing several other tumor types, offering a promising approach for enhancing cytological diagnosis.

As brain-computer interfaces become increasingly precise in reading human emotions, a practical question arises: Will a model trained today still be able to recognize the emotions of the same person tomorrow, in a few weeks, or even months later? Recently, the team led by Shuang Liu from the Medical School of Tianjin University/Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration published a research paper titled "Toward Sustainable Cross-Time Affective Brain–Computer Interfaces: Explicit Modeling and Structural Calibration of Temporal Variability" in the National Science Review (NSR). This study offers a cross-time "EEG ruler" for affective brain-computer interfaces (aBCIs). To address temporal variability in cross-time emotion recognition, the researchers propose a Multi-level Dynamic Integrated Perception Network (MDIN), which explicitly models and structurally calibrates temporal variability on three levels: emotional neural representation, dynamic functional connectivity, and cross-time discriminative structures, offering a new technical pathway for long-term stable affective brain-computer interfaces. This work may further accelerate the transition of aBCIs from short-term experimental validation to long-term, adaptive use in real-world mental health monitoring and human-machine interaction.