Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is increasingly understood as a malignancy shaped by profound changes in cellular metabolism. A comprehensive review published in Genes & Diseases highlights how these metabolic alterations contribute to tumour growth, immune evasion and treatment resistance, while revealing potential opportunities for new therapeutic approaches.

A review published in Genes & Diseases highlights the complex interplay between protein arginine methylation and ubiquitination, two forms of protein modification that can profoundly influence cancer development, progression and treatment response. The article brings together current understanding of how these interconnected molecular processes regulate proteins involved in cancer and identifies opportunities for future therapeutic approaches.

Triple-negative breast cancer (TNBC) remains one of the most challenging forms of breast cancer to treat because it lacks the estrogen, progesterone and HER2 receptors that enable targeted treatment in other breast cancer subtypes. A review published in Genes & Diseases examines how targeting the epidermal growth factor receptor (EGFR) alongside other molecular targets, supported by nanocarrier-based delivery, could offer new possibilities for more precise TNBC treatment.

China’s agriculture has long faced three major problems: excessive chemical fertilizer application, residual mulch film pollution, and low utilization rates of livestock and poultry manure. Excessive fertilizer input leads to soil acidification and compaction, and nutrient use efficiency continues to decline. Traditional polyethylene (PE) mulch film is difficult to degrade, and its year-by-year accumulation forms microplastic pollution, damaging soil microbial communities and arable land health. At the same time, livestock waste such as cow manure is large in volume and widely distributed, but its resource utilization pathways are limited, and crop-livestock cycling is not smooth. The green transformation of agriculture urgently needs integrated technologies that simultaneously ensure stable yields, reduce fertilizer use, reduce plastic pollution, and improve soil fertility.