Platinum resistance remains a major obstacle in ovarian cancer treatment. Circular RNAs (circRNAs) have emerged as important regulators of cancer progression and drug resistance. This study identified circSFPQ_008 as a key driver of platinum resistance in ovarian cancer through the circSFPQ_008/SFPQ/BRCA1 axis. Targeting this pathway sensitized ovarian cancer cells to platinum chemotherapy, suggesting a promising therapeutic strategy for overcoming drug resistance. These findings provide new insights into the molecular mechanisms of platinum resistance and identify potential therapeutic targets for ovarian cancer.

A research team has developed the Coastal Water Pathogen Database (CWPD), an open-access platform that integrates metagenomic evidence on pathogenic bacteria, viruses and fungi in coastal waters with information on antibiotic resistance genes and virulence factors. 

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, underscoring the need for effective therapies. Although miR-125b-5p shows therapeutic potential, its efficacy in metabolic dysfunction-associated steatotic liver disease (MASLD)-related HCC and the underlying mechanisms remain unclear. In this study, we aimed to develop a magnetic resonance imaging (MRI)-trackable miR-125b-5p-engineered MSC platform for HCC therapy and to determine whether MASLD attenuates its antitumor efficacy through metabolic reprogramming.

Hiroshima University researchers show that natural tooth count serves as a prognostic marker associated with long-term overall survival following pancreatectomy for the treatment of pancreatic ductal adenocarcinoma. 

Grounding intermittent art festivals such as the Setouchi Triennale within the resource capacities and social thresholds of the island communities that host them is a path to the sustainable long-term revitalization of these communities.

Atmospheric water vapor is vital to weather and climate research, yet estimating it from global navigation satellite system (GNSS) signals depends on an intermediate temperature value that global models may not represent accurately at regional scales. In Geodesy and Geodynamics, researchers introduce three models calibrated for Iran using radiosonde observations and radio occultation profiles from multiple satellite missions. Models using measured surface temperature performed best with radiosonde data, while a surface-temperature-independent model proved more reliable for satellite profiles and cut errors in GNSS-derived precipitable water vapor by about half at test stations in Tehran and Tabriz.

The Natural Product Institute at the Gangneung Institute of the Korea Institute of Science and Technology (KIST, President Oh Sang-Rok) has long conducted research leveraging natural-product-based core technologies to improve public quality of life. Building on this research foundation, a team led by Dr. Koo Song Yi, Senior Researcher at the Center for Natural Product Systems Biology, has developed a 3D food printing-based manufacturing technology for customized medi-foods. To address the mealtime challenges faced by dysphagia patients, the team engineered a composite ink for 3D printing that allows precise control of physical properties tailored to each patient's individual swallowing ability.

What if cancer screening no longer had to look for one cancer at a time? Cancer screening has long followed a one-organ-at-a-time model: mammography for breast cancer, colonoscopy for colorectal cancer, low-dose CT for lung cancer, and cervical testing for cervical cancer. These programs save lives, but they also leave gaps. Many cancers still lack routine screening, while patients often face multiple appointments, tests, and follow-up procedures.