Researchers from Wuhan University of Technology have developed a laser-stepwise-induced graphene (LSIG) method that significantly lowers sheet resistance to just 15 Ω sq^-1. By combining focused and defocused laser pulses, this technique reduces structural defects and improves crystallinity in laser-induced graphene, enabling advanced applications in electromagnetic shielding and infrared stealth.

Researchers have developed a magnetic, transferrin-modified liposomal delivery system (HM@MNLs-Tf) to improve the brain-targeted therapy of glioblastoma using harmine, a plant-derived anti-cancer compound. By leveraging transferrin receptor-mediated targeting and an external magnetic field, the system efficiently crosses the blood-brain barrier, selectively delivers harmine to glioma cells, and minimizes neurotoxic side effects. In preclinical studies, HM@MNLs-Tf demonstrated enhanced tumor accumulation, significant inhibition of tumor growth, and reduced central nervous system toxicity, offering a promising strategy for precise and safe glioblastoma treatment.

CAR-T therapy for solid tumors faces challenges including immune evasion, suppressive microenvironment, and off-target toxicity. Nanotechnology—especially mRNA-loaded lipid nanoparticles (LNPs), hydrogels, and photothermal/acoustogenetic modulation—offers solutions. mRNA enables transient, safe CAR expression. LNPs can be engineered for targeted delivery. Preclinical ovarian cancer studies show promise (e.g., nfP2X7 CAR-T, multifunctional nanoparticles). This review highlights how nanotechnology enhances CAR-T safety, precision, and efficacy.

Malignant cutaneous melanoma is the most invasive and metastatic type of skin cancer. Surgical resection, the conventional treatment for it, is associated with two major issues: incomplete tumor removal, which easily leads to recurrence, and poor healing of large postoperative wounds. Additionally, acral lentiginous melanoma (ALM) is a common subtype of this cancer. The existing bulky dressings used for ALM are prone to falling off during joint movement, significantly compromising the therapeutic effect. To address these problems, we have developed a nanocomposite hydrogel wound patch (M_xNd/yCe@M SAC). By adopting a cascaded sequential therapy strategy, this patch is specifically designed to solve the key challenges of high recurrence rate and poor wound healing after melanoma surgery.

Electrochemical CO₂ reduction (CO₂RR) to formate offers a sustainable pathway for carbon utilization under mild conditions. However, its practical application is hindered by the high energy consumption of the anodic oxygen evolution reaction (OER). Replacing OER with the methanol oxidation reaction (MOR) enables simultaneous formate production at both electrodes and significantly lowers the overall energy input. Recently, the research group of Professor Junfeng Xie at Shandong Normal University has developed a two-electrode system featuring a crystalline/amorphous Bi-BiNiO_x/NF cathode and a β-Ni(OH)₂ anode for efficient formate synthesis.

A research team from China has developed a tuning strategy to enhance the conventional chiral seeded growth method. By incorporating a pre-incubation step involving seeds and chiral ligands, the team aimed to control the initial symmetry breaking by modulating their interactions. Under optimized incubation conditions, chiral plasmonic nanorods (CPNRs) exhibiting high chiroptical responses were successfully synthesized. These resulting CPNRs were used to explore the enhancement mechanism of silver ions in the plasmon-mediated oxidative coupling reaction of 4-aminothiophenol.  

A review in the Chinese Journal of Natural Medicines examines how natural products can improve the in vivo fate of mesenchymal stem cells (MSCs), with potential benefits for cell homing, survival, differentiation, and immunoregulatory function in regenerative medicine and disease treatment.

A study in the Chinese Journal of Natural Medicines reports the first high-resolution structure of the major G-quadruplex in the TMPRSS2 promoter and shows how berberine binds and stabilizes it, offering a structural basis for antiviral strategies aimed at suppressing TMPRSS2 expression.

A scientific team from the Universidad Carlos III de Madrid (UC3M) has refined the operation of Bindi, an emotion-detection system in wearables capable of identifying fear in real-time during abuse situations to trigger automatic aid protocols. Their latest breakthrough involves integrating deep learning algorithms—an advanced branch of Artificial Intelligence (AI)—enabling detection without the need for remote servers, thereby reducing energy consumption and the transmission of sensitive information.