Skin flaps are essential in reconstructive surgery, but their success can be threatened when blood flow fails to reach the farthest tissue. 

Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People’s Hospital, published a review entitled “Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer”. Aligned with the paradigm shift toward precision medicine and individualized management in prostate cancer, this review systematically summarizes the adaptive changes in intratumoral androgen metabolism and androgen receptor (AR) signaling during disease progression from hormone-sensitive prostate cancer (HSPC) to castration-resistant prostate cancer (CRPC) and the highly aggressive subtypes (DNPC and NEPC) emerging during castration resistance, along with research advances in how these mechanisms contribute to therapy resistance. Furthermore, the review critically analyzes current challenges in studying prostate cancer resistance, and outlines future directions toward high-throughput, refined, and personalized strategies, emphasizing the integration of multi-omics technologies and novel in vitro and in vivo models to advance mechanistic insights into drug resistance, thereby establishing a scientific foundation for optimizing individualized therapeutic approaches.

Diabetic foot ulcers can remain open for weeks or months, leaving patients at risk of infection, hospitalization, and amputation.

Underwater landslides are a destructive force, putting vital submarine infrastructure at serious risk and can even generate damaging tsunamis. By analyzing research completed from 2000 to 2025, scientists tracked this phenomenon to better understand what triggers the landslides, how they move and generate tsunamis, and the dangers they pose.

A novel sprayable nanozyme dressing developed by Chinese researchers effectively treats aerobic vaginitis by combining antibacterial, anti-inflammatory, and microbiome-regulating properties. Tested in mice, the dressing not only alleviated infection and inflammation but also restored reproductive function and pregnancy rates, offering a promising non-antibiotic strategy for gynecological care.