By the time Alzheimer’s disease begins affecting a person’s memory, the underlying changes in the brain may have been developing for decades.

That delay limits opportunities for early intervention by the time most people receive a diagnosis. Current diagnostic tools often rely on costly brain imaging, blood tests or cognitive evaluations that are typically performed only after symptoms become noticeable.

A Texas A&M University research team is investigating whether another clue appears much earlier: the way people walk.

Supported by a Dementia and Alzheimer’s Research Initiative (DARI) seed grant, lead researcher Dr. Jenna Yentes, associate professor in the Department of Kinesiology and Sport Management, is studying whether detailed measurements of gait can identify the earliest biological markers of Alzheimer’s disease and related dementias in adults who have not yet developed cognitive symptoms. The work could lay the foundation for a practical tool to identify people who may benefit from further evaluation years before memory loss appears.

When it comes to daily aches and pains, it’s not uncommon for our knees to be a main source. And while there can be many different long-term causes of such issues, osteoarthritis often is a reason why, especially as we age. In knee osteoarthritis, the cartilage between knee bones wears down. In a healthy knee, this cartilage helps the joint move smoothly and also helps protect it. When that cartilage thins and wears down, problems can begin — and often get worse over time. For people with osteoarthritis, healthy behaviors and other treatments can help deal with symptoms, like pain and poor mobility — and may even slow worsening of the condition.