Precise construction of chiral cyclic imine esters by transient binary copper co-catalysis
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-May-2026 20:15 ET (23-May-2026 00:15 GMT/UTC)
Recently, a collaborative team from Shanghai Jiao Tong University, led by Guoqiang Yang, Wanbin Zhang, and Jianming Zhang, reported an asymmetric bimetallic synergistic CuAPS (copper-catalyzed propargyl substitution reaction) strategy. By activating the propargyl electrophile and the α-cyano ester nucleophile respectively using a chiral Cu(I)–BOX complex catalyst, and through a transient binuclear catalytic mechanism, they achieved the tandem cyclization of asymmetric propargyl substitution and the Pinner reaction to construct chiral cyclic imine esters. The article was published as an open access Research Article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.
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