A new study introduces a novel injectable composite microsphere that combines cells and biomaterials to significantly accelerate bone healing.

This is the first unequivocal record of the species outside its type locality in Dorset, UK, and the largest specimen known to date.

A new study in Science Bulletin reveals that maternal PAN2 protein is essential for early embryonic development by regulating mRNA poly(A) tail length. Using an oocyte-specific conditional knockout mouse model, researchers found that PAN2 deficiency causes embryos to arrest at the two-cell stage due to abnormal poly(A) tail elongation, maternal mRNA accumulation, and impaired zygotic genome activation. PAN2 recognizes substrates via the PAN3-PABPC1 complex, preferring tails lacking guanosine but enriched in uridine.

A comprehensive in silico scan of human respiratory viruses identified 3CLpro cleavage motifs within influenza NP and PA. Experimental validation confirmed that 3CLpro-mediated cleavage triggers rapid protein degradation and cytoplasmic mislocalization. Consequently, both ectopic 3CLpro expression and SARS-CoV-2 replication effectively inhibit replication across diverse influenza virus strains, revealing a broad-spectrum antiviral mechanism.