Hormonal fluctuations associated with fertility are associated with a greater tendency for women to use conspicuous luxury symbols, potentially to be noticed by men, according to a study published September 2, 2026, in the open access journal PLOS One by Aekyoung Kim of Jeonbuk National University of the Republic of Korea, and colleagues.

Texas A&M University researchers discover how meal timing triggers a nutrient-signaling pathway that drives rhythmic gene activity in the liver, independently of its circadian clock. The findings suggest that when we eat may be just as important as what we eat, raising new questions about what happens when our feeding schedule is out of sync with our body’s circadian clock.

Corneal disorders remain a leading cause of visual impairment worldwide, with limited treatment options for many conditions including severe dry eye disease, corneal ulcers, scarring, and dystrophies. Exosomes, nanoscale extracellular vesicles carrying diverse bioactive molecules, have emerged as a promising therapeutic modality for corneal disease. This comprehensive review examines the current landscape and future outlook of exosome-based therapies in ophthalmology, focusing on corneal disorders. The authors summarize the fundamental biology of corneal exosomes and their roles in maintaining corneal homeostasis and driving disease processes. Robust preclinical evidence demonstrates that exosomes can promote epithelial wound healing, modulate inflammation and fibrosis, and support tissue regeneration across major corneal conditions. Emerging clinical studies are beginning to assess safety and feasibility in human patients. The review also addresses critical aspects of exosome isolation, characterization, engineering, and delivery strategies relevant for clinical translation. Despite encouraging findings, major challenges remain in standardizing manufacturing and quality control, ensuring long-term safety, and achieving consistent therapeutic efficacy. Future research should prioritize optimization of exosome production and delivery, rational engineering to enhance performance, and exploration of exosomes as diagnostic biomarkers, collectively paving the way for transforming corneal disease management.

Bupleuri Radix (BR), a cornerstone traditional Chinese medicine, has been used for millennia to treat liver and intestinal disorders, yet its dual nature as both a hepatoprotective agent and a potential hepatotoxin demands rigorous scientific examination. This innovative review systematically synthesizes the bidirectional effects of BR through the lens of the gut-liver axis, a biological framework that has transformed our understanding of drug metabolism and toxicity. Saikosaponins, the principal bioactive constituents of BR, undergo biotransformation by gut microbiota into metabolites with enhanced bioavailability, enabling them to regulate intestinal flora composition, strengthen intestinal barrier integrity, and alleviate inflammation through key signaling pathways including NF-κB, PI3K/Akt/mTOR, and STAT3. Simultaneously, BR and its components exert hepatoprotective effects through antioxidant, anti-inflammatory, and metabolic regulatory mechanisms. However, the review also critically examines evidence that saikosaponins and volatile oils may induce hepatotoxicity via oxidative stress and apoptotic pathways. The authors identify critical evidence gaps regarding the systematic interplay between BR's multi-component actions and the gut-liver axis, the toxicity of microbial metabolites, and clinical hepatotoxicity risk, proposing a future research agenda to optimize the safe and effective clinical application of this important medicinal herb.

Hematopoietic loss of chromosome Y (LOY) has emerged as one of the most prevalent somatic genomic alterations in aging males, yet its biological significance extends far beyond a mere marker of aging. This comprehensive review synthesizes current understanding of LOY, from its molecular origins in mitotic chromosome mis-segregation to its far-reaching clinical implications. Advances in detection technologies, including single-cell sequencing and bulk genomic approaches, have enabled robust identification of LOY across population scales. The review examines how inherited genetic variation, environmental exposures, and aging collectively contribute to LOY pathogenesis. Large-scale genome-wide association studies have revealed compelling epidemiological links between hematopoietic LOY and cardiovascular disease, neurodegenerative conditions, immune disorders, and cancer. Mechanistically, LOY drives altered gene expression, immune dysregulation, and clonal expansion of affected hematopoietic cells. Critically, CRISPR-based mouse and cellular models have recapitulated key disease phenotypes, establishing LOY as a functionally consequential form of somatic mosaicism with profound implications for disease susceptibility and male health disparities.

CAMBRIDGE, Mass., September 2 - Insilico Medicine (“Insilico”; HKEX: 3696), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced the release of a series of frontier specialist models for chemistry and biology, trained through its MMAI Gym for Science framework. Across chemistry and biology, the models demonstrate state-of-the-art (SOTA) performance on more than 50 benchmark tasks.