Why her sister and not her: inside the gap that schizophrenia genetics has not closed
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Updates every hour. Last Updated: 23-Oct-2026 02:16 ET (23-Oct-2026 06:16 GMT/UTC)
Twin studies place the heritability of schizophrenia near eighty percent, but concordance between monozygotic twins falls well short of fifty percent. What occupies the remaining distance is unresolved. Consuelo Walss-Bass, who directs the Psychiatric Genetics Program and the brain collection at UTHealth Houston, approaches the problem through transcriptomic and epigenetic profiling of donated brain tissue and through induced pluripotent stem cell models derived from families with multiple affected siblings. She also grew up with the question: her mother had schizophrenia, and of five children raised afterward in Torreón, Mexico, one received the same diagnosis. Why My Sister? sets the two accounts alongside each other.
New research from the Marshall University Joan C. Edwards School of Medicine provides insight into how binge alcohol exposure during adolescence may cause lasting changes in brain function that persist into adulthood, potentially identifying a new target for future treatment approaches.
The study, published August 15 in Molecular Psychiatry, found that intermittent ethanol exposure during adolescence disrupted communication between astrocytes—supportive brain cells increasingly recognized for their role in neural signaling—and synapses in the hippocampus, a region of the brain important for learning and memory.
A new study of aging in our organs found that each organ ages on its own schedule. Arteries remodel fastest from age 30-39 while reproductive organs do so at menopause.
Most of our body ages in two waves, and those who experience aging more rapidly in one organ also have accelerated aging in partner organs. The researchers built a map from analyzing 25,000 organ images that points to hormonal signaling as a possible conductor of this symphony of aging throughout the body.Borrowing from the study of complex systems like flocks of birds and microbial communities, UChicago researchers built AI tools that compare the spatial organization of tumors — a step toward personalized cancer treatment.