The launch of Pathology Research provides a new interdisciplinary platform bridging experimental pathology, clinical diagnostics, and cutting-edge technologies such as spatial multi-omics, artificial intelligence, and multimodal integration. Grounded in the emerging concept of the “disease ecosystem,” the journal integrates microenvironment, microbiota, metabolic regulation, and neuro–immune crosstalk into a unified analytical framework, aiming to accelerate translational innovation and reduce the global burden of cancer and other complex diseases.

This review examines the evolution of digital pathology and artificial intelligence over the past decade, covering whole-slide imaging, image management, AI-assisted diagnosis, biomarker quantification, and prognostic prediction, while exploring emerging directions such as multimodal foundation models and agentic AI.

Using a new combination of computational tools to analyze ancient DNA, Yale researchers have discovered two ancient, extinct giant tortoise lineages that once lived on the Galapagos Islands.

The researchers’ pioneering approach, which employs computational genome analysis tools, showed that museum specimens previously considered too genetically degraded to be useful in this type of research can help reveal evolutionary history. The findings could also aid ongoing efforts to expand giant tortoise populations in the Galapagos archipelago.

Results of the study are published in the journal Proceedings of the Royal Society B.

A new collaborative study from the laboratories of Drs. Xaralabos Varelas and Giovanni Ligresti from Boston University Chobanian & Avedisian School of Medicine have identified a distinct population of cells located in lung veins that becomes active after injury and helps create an environment that promotes scar tissue formation, a process known as fibrosis. Identifying a previously unrecognized driver of lung fibrosis and a signaling pathway that can be targeted, offers new opportunities for developing therapies to prevent, or slow disease progression in pulmonary fibrosis and other fibrotic lung diseases.

When a pregnancy ends early and unexplained, the search for answers usually begins with the mother. Lacey Luense, Ph.D., wants to know what the father’s sperm might have to do with it.