Understanding the diverse chemokine signals in tumor microenvironment for advanced immunotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jun-2026 00:16 ET (16-Jun-2026 04:16 GMT/UTC)
Chemokines, acting as "traffic controllers" in the tumor microenvironment, regulate immune cell infiltration and local immunity. This review summarizes the chemokine expression profiles in tumors, their diverse roles in pro- and anti-tumor immunity, current targeting strategies (inhibition, delivery, engineering), and synergistic potential ability with other immunotherapies. Despite challenges, targeting the chemokine receptor axis holds great promise for reprogramming the tumor microenvironment and advancing precision cancer therapy.
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