A new manufacturing method could help move the production of nanoscale sensors from specialized fabrication facilities to conventional semiconductor manufacturing plants.

Why do some tissues regenerate efficiently after injury while others develop chronic inflammation, scar formation, or even fibrosis? A newly published review proposes that immunometabolism is not a universal "pro-inflammatory or anti-inflammatory" program but a dynamic adaptation process shaped by organ structure, regenerative capacity, injury stage, and local microenvironment. The article systematically compares six tissues—intestine, skin, liver, lung, heart, and skeletal muscle—and introduces the concept of niche-dependent immunometabolic regulation.

Acting as an armor, a scaffold, and a communication platform, the plasma membrane lies at the heart of many crucial cellular processes. Now, researchers at OIST and collaborating institutions have revealed a crucial yet often overlooked membrane component: complex sugar chains, known as glycans. They found that glycans carried by gangliosides form weak, short-lived pairs through repeated "fleeting encounters," helping build membrane nanodomains and regulate epidermal growth factor receptor (EGFR) signaling, which in turn modulates cell division. 

When proteins and lipids interact at the cell surface, they kick off essential cellular signaling pathways that play a role in physiological processes throughout the body. When these interactions and signaling pathways are disrupted, it can create conditions where cells can grow out of control and turn into tumors or other diseases. Therefore, understanding how these molecules interact at the cell surface may help inform the development of more targeted therapies in the future. Beyond proteins and lipids, polymers made of sugars called glycans that form a layer on the cell surface also seem to play a similarly important role that has yet to be completely understood.

Researchers from Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) recently observed a species of armored searobin, Scalicus engyceros, walking sideways and backward on the sea floor in the South China Sea. This is the first time a species of fish has been observed walking backward.

Researchers at the University of California, Davis, have demonstrated that directed evolution can dramatically improve the desiccation tolerance of Gram-negative bacteria during industrial spray-drying—without changing a single ingredient in the protective formulation. Published in Systems Microbiology and Biomanufacturing, the study shows that iteratively selecting survivors of the drying process boosted viable cell counts in the final powder by over 1,000-fold, reaching 3.07×10¹⁰ CFU/g.

A temporally biosynchronized and physically transient peripheral nerve interface (NeuroSyn) is designed to continuously monitor nerve regeneration and decode movement intentions during the post-injury repair phase. In a rat model, it achieves excellent motor intention recognition using peripheral nerve signals, outperforming signals recorded from the primary motor cortex (M1), which holds promise for exoskeleton-based rehabilitation training. Once the nerve heals, the device harmlessly degrades, eliminating the need for a second surgery and holding potential for advanced neuroregeneration monitoring and adaptive neurorehabilitation.

An optimized methodological innovative workflow unlocks the potential of stored biobank whole-blood samples for multi-omics research and diagnostic and prognostic biomarker discovery.