Cancer Research UK-funded researchers find dementia-like behaviour in pancreas cells at risk of turning into cancer. The researchers noticed excess “problem protein” molecules forming clumps in these cells, a common feature seen in neurological disease. While early stage, the findings give clues for new ways to study, treat, or potentially prevent pancreatic cancer, a particularly deadly cancer type.

The first weeks outside the womb are a massive learning experience for the neonatal immune system, especially in the gut as it learns to distinguish helpful from harmful antigens. In mice, maternal antibodies ingested in breast milk in the first week after birth help to regulate immune responses in the newborn gut, according to a new study by Meera Shenoy and colleagues. This process builds the important partnership between the microbiome and host at an early stage, paving the way for nutrient assimilation, avoiding inappropriate inflammation and resistance against pathogens. Shenoy et al. found that mouse maternal immunoglobin G antibodies bind to bacteria in the neonatal gut to modulate the immune response in the gut mucosa. This antibody-bacteria complex binds to antibody receptors in the gut to limit the response of T cells to food antigens during weaning and in response to experimentally induced colitis during early life. “Translating these findings to human infants will require studies integrating information on the timing of exposure to maternal antibodies, along with the development of key immune components and the intestinal microbiota,” Michael Silverman and Kathryn Knoop write in a related Perspective.