An ultrasound-responsive micronanorobot combines a collagenase-secreting bacterium, bismuth ferrite nanoparticles, the drug DM4 and a targeting ligand to treat nonmuscle-invasive bladder cancer. After intravesical delivery, it degrades tumor matrix, enhances drug penetration, and ultrasound triggers reactive oxygen species, achieving 90.8% cell death in vitro and 82.4% tumor inhibition in mice. The system also promotes antitumor immunity, increasing CD8+ T-cell infiltration and shifting macrophages toward the M1 phenotype.

A study by Graz University of Technology (TU Graz) shows that algorithms used by short-form video platforms are particularly effective at keeping people with ADHD engaged. This “engagement trap” often leads to wasted time and emotional stress. The EU is currently considering stricter rules for services such as TikTok.

A study published in the Journal of Bioresources and Bioproducts examines whether hydrophilic deep eutectic solvents (DESs) can provide a technically and economically viable alternative to conventional pre-hydrolysis Kraft pulping for dissolving pulp production. Using Aspen Plus process simulation together with techno-economic analysis, life-cycle assessment, sensitivity analysis and Monte Carlo uncertainty analysis, the researchers evaluated five process configurations at an industrially relevant scale. The results indicate comparable pulp yields, while revealing that DES recovery and energy consumption remain major barriers to competitiveness. A pre-hydrolysis-assisted configuration achieved the lowest modeled minimum selling price of 1,330 yuan per air-dry metric ton. The analysis also shows that economic and environmental performance do not necessarily favor the same process configuration.

A perspective published in the Journal of Bioresources and Bioproducts examines the emerging role of silk fibroin (SF)/polylactic acid (PLA) composite scaffolds in bone and related tissue regeneration. The review brings together evidence on material chemistry, scaffold architecture, interfacial bonding, degradation, mechanotransduction, osteogenesis, angiogenesis and immunomodulation. Rather than treating fabrication methods or biological responses separately, the authors discuss how these factors interact to determine scaffold performance. The review also assesses evidence across in vitro, animal and translational studies, concluding that substantial work remains before SF/PLA scaffolds can move toward human clinical applications.