Bridge recombinases, optimized for human cells, enable massive programmable DNA rearrangements
Peer-Reviewed Publication
Updates every hour. Last Updated: 9-Oct-2025 01:11 ET (9-Oct-2025 05:11 GMT/UTC)
In a paper published September 25, 2025 in the journal Science, Arc Institute researchers show how bridge recombinase technology can be applied to human cells. The advance allows scientists to manipulate large genomic regions, testing up to a million base pairs in length, by inserting new genes, deleting entire gene clusters, or inverting regulatory sequences.
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