AI-driven biomarker model may improve detection of cancer cachexia
Reports and Proceedings
Updates every hour. Last Updated: 30-Apr-2025 14:08 ET (30-Apr-2025 18:08 GMT/UTC)
In places like Australia, where metropolitan areas are separated by an entire continent, donor hearts used to go unused simply because transplant teams couldn’t get the organ to a recipient in time. Emily Granger, MBBS, cardiothoracic and heart and lung transplant surgeon at St. Vincent's Hospital, Sydney, Australia, addressed organ transportation time at today’s Annual Meeting and Scientific Sessions of the International Society of Heart and Lung Transplantation (ISHLT) in Boston.
A research paper by scientists at Beijing Institute of Technology presented a CFD simulation method based on biological experimental data to analyze the aerodynamic performance of pigeons during takeoff, leveling flight, and landing in free flight.
Novel cancer therapy combining multi-hydroxylated fullerene (MF) nanoparticles and mTOR inhibitors triggers organelle cascade collapse in tumors, disrupting cancer cells' self-repair capacity. By synchronizing the membrane-breaking effect of MF with dual autophagy regulation, this strategy induces lysosomal rupture, mitochondrial dysfunction, and endoplasmic reticulum stress while paralyzing cellular cleanup systems. Animal studies demonstrate potent tumor suppression and high safety, leveraging cancer cells' fragile organelle networks against them. The breakthrough establishes organelle communication disruption as a new anticancer paradigm, pioneering material science-enabled therapies independent of genetic targets.
Mononuclear macrophages serve as the primary target cells for the in vivo metabolism of iron-based nanomaterials. The uptake of nanoparticles by mononuclear macrophages is influenced by various factors, such as particle size, surface charge, and administration route, which subsequently affect the metabolic process. During this process, iron-based magnetic nanomaterials can induce macrophage reprogramming and participate in immune modulation. This is primarily reflected in their regulation of macrophage function through enzyme-like activities, intracellular iron metabolism, cell signaling pathways, mitochondrial energy metabolism, and responses to magnetic fields.
A research paper by scientists at Beijing Institute of Technology presented a steering control strategy for cyborg insects in operant learning training of cockroaches in a T-maze. Cockroaches developed a preference for specific maze channels after only five consecutive sessions of unilateral cercus electrical stimulation and steering behavior induction, achieving a memory score of 83.5%, outperforming traditional punishing training schemes.